2019 |
M., Gómez-Díaz Corcuera-Flores Torres-Lagares Ruiz-Villandiego Machuca-Portillo Gutiérrez-Pérez Serrera-Figallo Baus-Domínguez R J R D J C G J L M A Metallothioneins in Failure of Dental Implants and Periodontitis Down Syndrome Patients Artículo de revista Genes (Basel), 10 (9), pp. E711, 2019. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{Baus-Domínguez2019, title = {Metallothioneins in Failure of Dental Implants and Periodontitis Down Syndrome Patients}, author = {Gómez-Díaz Corcuera-Flores Torres-Lagares Ruiz-Villandiego Machuca-Portillo Gutiérrez-Pérez Serrera-Figallo R J R D J C G J L M A Baus-Domínguez M.}, doi = {10.3390/genes10090711}, year = {2019}, date = {2019-09-14}, journal = {Genes (Basel)}, volume = {10}, number = {9}, pages = {E711}, abstract = {BACKGROUND: Sometimes dental implants seem to be the only therapeutic alternative for the oral rehabilitation of patients with Down syndrome, given that they usually lose all their teeth early due to suffering aggressive periodontitis and they do not usually have the skills required to wear removable prostheses. However, the evolution of dental implants in these patients shows very adverse results. It is possible that basal genetic alterations, or at least some characteristics of these, may underlie these clinical results. The metabolic pathway of metallothioneins, molecules with an important influence on bone metabolism, could be one of the said alterations. AIMS: To determine whether the expression of metallothioneins (MTs) and their metabolic pathway may be identified and related to the periodontitis and lack of osseointegration of dental implants in Down syndrome patients. MATERIALS AND METHODS: Retrospective study of cases and controls by comparing patients with Down syndrome, periodontal disease, and implant failure (four patients, test group) with patients with Down syndrome, without periodontal disease, and without implant failure after two years of following (seven patients, control group), by extracting peripheral blood at the time of the dental examination to extract RNA and its subsequent processing in relation to gene expression of the metabolic pathway of metallothioneins. RESULTS: The results identified low expression in the group of patients with periodontal disease and implant failure of genes MT1E, MT1H, MT1X, MT1A, MT1B, MT1C, MT1L, MT2A, MT1M, and MT1G. CONCLUSIONS: The low MT1 and MT2 gene expression seems to be related to the onset of periodontal disease and implant rejection in Down syndrome patients, although more data are required to confirm whether this relationship is due to one of the two conditions, to both independently, or to the two jointly-this last option being indicated by our current study.}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } BACKGROUND: Sometimes dental implants seem to be the only therapeutic alternative for the oral rehabilitation of patients with Down syndrome, given that they usually lose all their teeth early due to suffering aggressive periodontitis and they do not usually have the skills required to wear removable prostheses. However, the evolution of dental implants in these patients shows very adverse results. It is possible that basal genetic alterations, or at least some characteristics of these, may underlie these clinical results. The metabolic pathway of metallothioneins, molecules with an important influence on bone metabolism, could be one of the said alterations. AIMS: To determine whether the expression of metallothioneins (MTs) and their metabolic pathway may be identified and related to the periodontitis and lack of osseointegration of dental implants in Down syndrome patients. MATERIALS AND METHODS: Retrospective study of cases and controls by comparing patients with Down syndrome, periodontal disease, and implant failure (four patients, test group) with patients with Down syndrome, without periodontal disease, and without implant failure after two years of following (seven patients, control group), by extracting peripheral blood at the time of the dental examination to extract RNA and its subsequent processing in relation to gene expression of the metabolic pathway of metallothioneins. RESULTS: The results identified low expression in the group of patients with periodontal disease and implant failure of genes MT1E, MT1H, MT1X, MT1A, MT1B, MT1C, MT1L, MT2A, MT1M, and MT1G. CONCLUSIONS: The low MT1 and MT2 gene expression seems to be related to the onset of periodontal disease and implant rejection in Down syndrome patients, although more data are required to confirm whether this relationship is due to one of the two conditions, to both independently, or to the two jointly-this last option being indicated by our current study. |
M., Gutierrez-Pérez Gutierrez-Corrales Serrera-Figallo Toledano-Osorio Rosales-Leal Aguilar Osorio Torres-Lagares Toledano J L A M A M J I M R D Novel non-resorbable polymeric-nanostructured scaffolds for guided bone regeneration Artículo de revista Clin Oral Investig., 2019. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{Toledano2019, title = {Novel non-resorbable polymeric-nanostructured scaffolds for guided bone regeneration}, author = {Gutierrez-Pérez Gutierrez-Corrales Serrera-Figallo Toledano-Osorio Rosales-Leal Aguilar Osorio Torres-Lagares J L A M A M J I M R D Toledano M.}, doi = {10.1007/s00784-019-03068-8}, year = {2019}, date = {2019-09-06}, journal = {Clin Oral Investig.}, abstract = {OBJECTIVE: The aim of this study was to evaluate the bone-regeneration efficiency of novel polymeric nanostructured membranes and the effect of zinc, calcium, titanium, and bone morpho-protein loading on membranes, through an in vivo rabbit model. MATERIAL AND METHODS: Nanostructured membranes of methylmethacrylate were loaded with zinc, calcium, TiO2 nanoparticles, and bone-morphogenetic protein (BMP). These membranes covered the bone defects prepared on the skulls of six rabbits. Animals were sacrificed 6 weeks after surgery. Micro computed tomography was used to evaluate bone architecture through BoneJ pluging and ImageJ script. Three histological processing of samples, including von Kossa silver nitrate, toluidine blue, and fluorescence by the deposition of calcein were utilized. RESULTS: Zn-membranes (Zn-Ms) promoted the highest amount of new bone and higher bone perimeter than both unloaded and Ti-membranes (Ti-Ms). Ca-membranes (Ca-Ms) attained higher osteoid perimeter and bone perimeter than Zn-Ms. The skeleton analysis showed that Zn-Ms produced more branches and junctions at the trabecular bone than BMP-loaded membranes (BMP-Ms). Samples treated with Ti-Ms showed less bone formation and bony bridging processes. Both Zn-Ms and Ca-Ms achieved higher number of osteoblasts than the control group. BMP-Ms and Ca-Ms originated higher number of blood vessels than Ti-Ms and control group. CONCLUSIONS: Zn incorporation in novel nanostructured membranes provided the highest regenerative efficiency for bone healing at the rabbit calvarial defects. CLINICAL RELEVANCE: Zn-Ms promoted osteogenesis and enhanced biological activity, as mineralized and osteoid new bone with multiple interconnected ossified trabeculae appeared in close contact with the membrane.}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } OBJECTIVE: The aim of this study was to evaluate the bone-regeneration efficiency of novel polymeric nanostructured membranes and the effect of zinc, calcium, titanium, and bone morpho-protein loading on membranes, through an in vivo rabbit model. MATERIAL AND METHODS: Nanostructured membranes of methylmethacrylate were loaded with zinc, calcium, TiO2 nanoparticles, and bone-morphogenetic protein (BMP). These membranes covered the bone defects prepared on the skulls of six rabbits. Animals were sacrificed 6 weeks after surgery. Micro computed tomography was used to evaluate bone architecture through BoneJ pluging and ImageJ script. Three histological processing of samples, including von Kossa silver nitrate, toluidine blue, and fluorescence by the deposition of calcein were utilized. RESULTS: Zn-membranes (Zn-Ms) promoted the highest amount of new bone and higher bone perimeter than both unloaded and Ti-membranes (Ti-Ms). Ca-membranes (Ca-Ms) attained higher osteoid perimeter and bone perimeter than Zn-Ms. The skeleton analysis showed that Zn-Ms produced more branches and junctions at the trabecular bone than BMP-loaded membranes (BMP-Ms). Samples treated with Ti-Ms showed less bone formation and bony bridging processes. Both Zn-Ms and Ca-Ms achieved higher number of osteoblasts than the control group. BMP-Ms and Ca-Ms originated higher number of blood vessels than Ti-Ms and control group. CONCLUSIONS: Zn incorporation in novel nanostructured membranes provided the highest regenerative efficiency for bone healing at the rabbit calvarial defects. CLINICAL RELEVANCE: Zn-Ms promoted osteogenesis and enhanced biological activity, as mineralized and osteoid new bone with multiple interconnected ossified trabeculae appeared in close contact with the membrane. |
M., Herráez-Galindo Torres-Lagares Serrera-Figallo Gutiérrez-Pérez Rizo-Gorrita C D M Á J L Biocompatibility of Polymer and Ceramic CAD/CAM Materials with Human Gingival Fibroblasts (HGFs) Artículo de revista Polymers (Basel)., 11 (9), pp. E1446, 2019. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{Rizo-Gorrita2019, title = {Biocompatibility of Polymer and Ceramic CAD/CAM Materials with Human Gingival Fibroblasts (HGFs)}, author = {Herráez-Galindo Torres-Lagares Serrera-Figallo Gutiérrez-Pérez C D M Á J L Rizo-Gorrita M.}, doi = {10.3390/polym11091446}, year = {2019}, date = {2019-09-03}, journal = {Polymers (Basel).}, volume = {11}, number = {9}, pages = {E1446}, abstract = {Four polymer and ceramic computer-aided design/computer-aided manufacturing (CAD/CAM) materials from different manufacturers (VITA CAD-Temp (polymethyl methacrylate, PMMA), Celtra Duo (zirconia-reinforced lithium silicate ceramic, ZLS), IPS e.max CAD (lithium disilicate (LS2)), and VITA YZ (yttrium-tetragonal zirconia polycrystal, Y-TZP)) were tested to evaluate the cytotoxic effects and collagen type I secretions on human gingival fibroblasts (HGFs). A total of 160 disc-shaped samples (Ø: 10 ± 2 mm; h: 2 mm) were milled from commercial blanks and blocks. Direct-contact cytotoxicity assays were evaluated at 24, 48, and 72 h, and collagen type I (COL1) secretions were analysed by cell-based ELISA at 24 and 72 h. Both experiments revealed statistically significant differences (p < 0.05). At 24 and 48 h of contact, cytotoxic potential was observed for all materials. Later, at 72 h, all groups reached biologically acceptable levels. LS2 showed the best results regarding cell viability and collagen secretion in all of the time evaluations, while Y-TZP and ZLS revealed intermediate results, and PMMA exhibited the lowest values in both experiments. At 72 h, all groups showed sharp decreases in COL1 secretion regarding the 24-h values. According to the results obtained and the limitations of the present in vitro study, it may be concluded that the ceramic materials revealed a better cell response than the polymers. Nevertheless, further studies are needed to consolidate these findings and thus extrapolate the results into clinical practice.}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } Four polymer and ceramic computer-aided design/computer-aided manufacturing (CAD/CAM) materials from different manufacturers (VITA CAD-Temp (polymethyl methacrylate, PMMA), Celtra Duo (zirconia-reinforced lithium silicate ceramic, ZLS), IPS e.max CAD (lithium disilicate (LS2)), and VITA YZ (yttrium-tetragonal zirconia polycrystal, Y-TZP)) were tested to evaluate the cytotoxic effects and collagen type I secretions on human gingival fibroblasts (HGFs). A total of 160 disc-shaped samples (Ø: 10 ± 2 mm; h: 2 mm) were milled from commercial blanks and blocks. Direct-contact cytotoxicity assays were evaluated at 24, 48, and 72 h, and collagen type I (COL1) secretions were analysed by cell-based ELISA at 24 and 72 h. Both experiments revealed statistically significant differences (p < 0.05). At 24 and 48 h of contact, cytotoxic potential was observed for all materials. Later, at 72 h, all groups reached biologically acceptable levels. LS2 showed the best results regarding cell viability and collagen secretion in all of the time evaluations, while Y-TZP and ZLS revealed intermediate results, and PMMA exhibited the lowest values in both experiments. At 72 h, all groups showed sharp decreases in COL1 secretion regarding the 24-h values. According to the results obtained and the limitations of the present in vitro study, it may be concluded that the ceramic materials revealed a better cell response than the polymers. Nevertheless, further studies are needed to consolidate these findings and thus extrapolate the results into clinical practice. |
F., Castillo-Oyagüe Oliveros-López Torres-Lagares Martínez-González Pérez-Velasco Lynch Gutiérrez-Pérez Serrera-Figallo Azcarate-Velázquez R L G D Á J A C D J L M Á Influence of bone quality on the mechanical interaction between implant and bone: A finite element analysis Artículo de revista J Dent., 88 (103161), 2019. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{Azcarate-Velázquez2019, title = {Influence of bone quality on the mechanical interaction between implant and bone: A finite element analysis}, author = {Castillo-Oyagüe Oliveros-López Torres-Lagares Martínez-González Pérez-Velasco Lynch Gutiérrez-Pérez Serrera-Figallo R L G D Á J A C D J L M Á Azcarate-Velázquez F.}, doi = {10.1016/j.jdent.2019.06.008}, year = {2019}, date = {2019-09-01}, journal = {J Dent.}, volume = {88}, number = {103161}, abstract = {OBJECTIVES: To evaluate the influence of bone type in terms of bone density and cortical bone thickness, on the stresses induced by two implants under compressive and oblique loads. METHODS: A numerical simulation technique based on the finite element method was applied. Two implant types (M-12 and Astra Tech) were introduced in a model matrix whose geometry was extracted from a real CBCT radiograph of the posterior mandibular region. The Young's module and Poisson's coefficient of the bone qualities described by Misch were calculated. Loads with amplitude of 400 N were exerted in two directions: compressive and 15° oblique to 5 mm above the uppermost part of the implant. RESULTS: The von Misses variant was analysed. Both implant types presented greater tension in the cortical bone area than in the trabecular bone region under compressive loading. For the oblique load condition, the stresses obtained in the cortical zone were significantly higher than those registered as a consequence of compressive loads in both implant types. CONCLUSIONS: Regardless of bone type, the M-12 implants presented lower tensions in the cortical bone than did the Astra implants. The tensions recorded for D3 and D4 bone types in the trabecular zone surrounding the M-12 implants were greater than those recorded for the Astra implants. CLINICAL SIGNIFICANCE: For both compressive and oblique loads, good mechanical behaviour was observed. The decrease in bone quality determines a worse stress distribution, and the cortical bone is overloaded. An efficient distribution of the forces may increase the implants' longevity.}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } OBJECTIVES: To evaluate the influence of bone type in terms of bone density and cortical bone thickness, on the stresses induced by two implants under compressive and oblique loads. METHODS: A numerical simulation technique based on the finite element method was applied. Two implant types (M-12 and Astra Tech) were introduced in a model matrix whose geometry was extracted from a real CBCT radiograph of the posterior mandibular region. The Young's module and Poisson's coefficient of the bone qualities described by Misch were calculated. Loads with amplitude of 400 N were exerted in two directions: compressive and 15° oblique to 5 mm above the uppermost part of the implant. RESULTS: The von Misses variant was analysed. Both implant types presented greater tension in the cortical bone area than in the trabecular bone region under compressive loading. For the oblique load condition, the stresses obtained in the cortical zone were significantly higher than those registered as a consequence of compressive loads in both implant types. CONCLUSIONS: Regardless of bone type, the M-12 implants presented lower tensions in the cortical bone than did the Astra implants. The tensions recorded for D3 and D4 bone types in the trabecular zone surrounding the M-12 implants were greater than those recorded for the Astra implants. CLINICAL SIGNIFICANCE: For both compressive and oblique loads, good mechanical behaviour was observed. The decrease in bone quality determines a worse stress distribution, and the cortical bone is overloaded. An efficient distribution of the forces may increase the implants' longevity. |
C., Rizo-Gorrita Luna-Oliva Serrera-Figallo Torres-Lagares Gutiérrez-Pérez González-Blanco M I M Á D J L Human Osteoblast Cell Behaviour on Titanium Discs Treated with Argon Plasma Artículo de revista Materials (Basel)., 12 (11), pp. E1735, 2019. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{González-Blanco2019b, title = {Human Osteoblast Cell Behaviour on Titanium Discs Treated with Argon Plasma}, author = {Rizo-Gorrita Luna-Oliva Serrera-Figallo Torres-Lagares Gutiérrez-Pérez M I M Á D J L González-Blanco C.}, url = {https://www.ncbi.nlm.nih.gov/pmc?term=31142007[PMID]&report=imagesdocsum}, doi = {10.3390/ma12111735}, year = {2019}, date = {2019-05-28}, journal = {Materials (Basel).}, volume = {12}, number = {11}, pages = {E1735}, abstract = {(1) Background. Titanium is characterized by its biocompatibility and resistance to stress and fatigue. Treatment with argon plasma may favour growth of human osteoblasts with respect to cell adhesion and proliferation. The aim of this study was to analyse the behaviour of human osteoblasts (MG-63) on Grade IV and V titanium possessing a sand-blasted, acid-etched (SLA) surface. SLA is a widely used surface treatment to create micro- and macroretentions to enhance osteoconductive properties on the surface. (2) Methods. One group of each grade of titanium was decontaminated with argon plasma and compared. On each disc, 20 × 104 cells were cultivated for morphological analysis, study of cell viability (regarding a negative control [100% viability]) and mitochondrial energy balance. (3) Results. At 24 h titanium treated with SLA showed a higher percentage of cell viability (47.3 ± 8.1%) compared to titanium IV treated with argon plasma, which presented a percentage of 79.1 ± 1.1%. Grade V titanium treated with argon plasma presented a higher viability percentage 91.3 ± 3.0% whereas nontreated Grade V titanium presented 53.3 ± 4.0%. Cells cultivated on the surfaces with an argon-plasma treatment were enlarged in comparison to non-treated discs. The cells with smaller circularity with a greater spread and spindle shape were the ones cultivated on the Grade V titanium surface. Cells seeded on treated titanium IV and titanium V, treated or not, showed higher mitochondrial activity over nontreated titanium IV. (4) Conclusions. Cells cultivated on those Grade V titanium discs that were decontaminated with argon plasma presented higher levels of cell adhesion and proliferation, lower mitochondrial damage and a higher mean cell area compared to those not decontaminated with argon plasma.}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } (1) Background. Titanium is characterized by its biocompatibility and resistance to stress and fatigue. Treatment with argon plasma may favour growth of human osteoblasts with respect to cell adhesion and proliferation. The aim of this study was to analyse the behaviour of human osteoblasts (MG-63) on Grade IV and V titanium possessing a sand-blasted, acid-etched (SLA) surface. SLA is a widely used surface treatment to create micro- and macroretentions to enhance osteoconductive properties on the surface. (2) Methods. One group of each grade of titanium was decontaminated with argon plasma and compared. On each disc, 20 × 104 cells were cultivated for morphological analysis, study of cell viability (regarding a negative control [100% viability]) and mitochondrial energy balance. (3) Results. At 24 h titanium treated with SLA showed a higher percentage of cell viability (47.3 ± 8.1%) compared to titanium IV treated with argon plasma, which presented a percentage of 79.1 ± 1.1%. Grade V titanium treated with argon plasma presented a higher viability percentage 91.3 ± 3.0% whereas nontreated Grade V titanium presented 53.3 ± 4.0%. Cells cultivated on the surfaces with an argon-plasma treatment were enlarged in comparison to non-treated discs. The cells with smaller circularity with a greater spread and spindle shape were the ones cultivated on the Grade V titanium surface. Cells seeded on treated titanium IV and titanium V, treated or not, showed higher mitochondrial activity over nontreated titanium IV. (4) Conclusions. Cells cultivated on those Grade V titanium discs that were decontaminated with argon plasma presented higher levels of cell adhesion and proliferation, lower mitochondrial damage and a higher mean cell area compared to those not decontaminated with argon plasma. |
E., Monsalve-Guil Casas-Barquero Jimenez-Guerra Torres-Lagares Segura-Egea Velasco-Ortega L N A D J Salivary secretion in patients with schizophrenia Artículo de revista J Biol Regul Homeost Agents., 33 (3), pp. 877-882, 2019. BibTeX | Etiquetas: publicaciones @article{Velasco-Ortega2019, title = {Salivary secretion in patients with schizophrenia}, author = {Monsalve-Guil Casas-Barquero Jimenez-Guerra Torres-Lagares Segura-Egea L N A D J Velasco-Ortega E.}, year = {2019}, date = {2019-05-01}, journal = {J Biol Regul Homeost Agents.}, volume = {33}, number = {3}, pages = {877-882}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } |
C., Rizo-Gorrita Luna-Oliva Serrera-Figallo Castillo-Oyagüe Torres-Lagares Herráez-Galindo M I M Á R D In vitro Comparative Study of Fibroblastic Behaviour on Polymethacrylate (PMMA) and Lithium Disilicate Polymer Surfaces Artículo de revista Polymers (Basel)., 11 (4), pp. E744, 2019. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{Herráez-Galindo2019b, title = {In vitro Comparative Study of Fibroblastic Behaviour on Polymethacrylate (PMMA) and Lithium Disilicate Polymer Surfaces}, author = {Rizo-Gorrita Luna-Oliva Serrera-Figallo Castillo-Oyagüe Torres-Lagares M I M Á R D Herráez-Galindo C.}, url = {https://www.ncbi.nlm.nih.gov/pmc?term=31027245[PMID]&report=imagesdocsum}, doi = {10.3390/polym11040744}, year = {2019}, date = {2019-04-25}, journal = {Polymers (Basel).}, volume = {11}, number = {4}, pages = {E744}, abstract = {Polymethyl methacrylate (PMMA) and lithium disilicate are widely used materials in the dental field. PMMA is mainly used for the manufacture of removable prostheses; however, with the incorporation of CAD-CAM technology, new applications have been introduced for this material, including as a provisional implant attachment. Lithium disilicate is considered the gold standard for definitive attachment material. On the other hand, PMMA has begun to be used in clinics as a provisional attachment until the placement of a definitive one occurs. Although there are clinical studies regarding its use, there are few studies on cell reorganization around this type of material. This is why we carried out an in vitro comparative study using discs of both materials in which human gingival fibroblasts (HGFs) were cultured. After processing them, we analyzed various cellular parameters (cell count, cytoskeleton length, core size and coverage area). We analyzed the surface of the discs together with their composition. The results obtained were mostly not statistically significant, which shows that the qualities of PMMA make it a suitable material as an implant attachment.}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } Polymethyl methacrylate (PMMA) and lithium disilicate are widely used materials in the dental field. PMMA is mainly used for the manufacture of removable prostheses; however, with the incorporation of CAD-CAM technology, new applications have been introduced for this material, including as a provisional implant attachment. Lithium disilicate is considered the gold standard for definitive attachment material. On the other hand, PMMA has begun to be used in clinics as a provisional attachment until the placement of a definitive one occurs. Although there are clinical studies regarding its use, there are few studies on cell reorganization around this type of material. This is why we carried out an in vitro comparative study using discs of both materials in which human gingival fibroblasts (HGFs) were cultured. After processing them, we analyzed various cellular parameters (cell count, cytoskeleton length, core size and coverage area). We analyzed the surface of the discs together with their composition. The results obtained were mostly not statistically significant, which shows that the qualities of PMMA make it a suitable material as an implant attachment. |
R.M., Delgado-Muñoz Serrera-Figallo González-Martín Torres-Lagares Gutiérrez-Pérez Díaz-Sánchez J M M A M I D J L Analysis of marginal bone loss and implant stability quotient by resonance frequency analysis in different osteointegrated implant systems. Randomized prospective clinical trial Artículo de revista Med Oral Patol Oral Cir Bucal., 1;24 (2), pp. e260-e264, 2019. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{Díaz-Sánchez2019, title = {Analysis of marginal bone loss and implant stability quotient by resonance frequency analysis in different osteointegrated implant systems. Randomized prospective clinical trial}, author = {Delgado-Muñoz Serrera-Figallo González-Martín Torres-Lagares Gutiérrez-Pérez J M M A M I D J L Díaz-Sánchez R.M.}, doi = {10.4317/medoral.22742}, year = {2019}, date = {2019-03-01}, journal = {Med Oral Patol Oral Cir Bucal.}, volume = {1;24}, number = {2}, pages = {e260-e264}, abstract = {BACKGROUND: The aim of the present prospective clinical study is to compare the stability of the implant-bone interface by the ISQ quotient and marginal bone loss (MBL) rate during one year of follow-up in four system implants with the same surface and different design. MATERIAL AND METHODS: Prospective randomized clinical trial of 21 patients in which four implant systems with the same surface and different design were placed. Patients were treated by the same operator following a similar surgical protocol with submerged technique. The second surgery to perform the prosthesis was performed at 3 months. All patients went to their review at 6 months and a year. A periapical radiograph for crestal bone analysis and an Implant stability quotient by resonance frequency analysis (ISQ) analysis were taken at baseline and the reviews. RESULTS: No statistically significant differences were found in the Implant stability quotient by resonance frequency analysis and Marginal Bone Loss in the four types of implants. The ISQ increased from the moment of insertion of the implant until the revision to the year, showing an increase of the stability implant, being this increasing less between the 6 months and the year. CONCLUSIONS: Differences in the design of the four implants tested in this study did not show statistically significant differences in any of the variables studied, so the implant design does not influence implant stability and marginal bone loss in the first year after placement.}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } BACKGROUND: The aim of the present prospective clinical study is to compare the stability of the implant-bone interface by the ISQ quotient and marginal bone loss (MBL) rate during one year of follow-up in four system implants with the same surface and different design. MATERIAL AND METHODS: Prospective randomized clinical trial of 21 patients in which four implant systems with the same surface and different design were placed. Patients were treated by the same operator following a similar surgical protocol with submerged technique. The second surgery to perform the prosthesis was performed at 3 months. All patients went to their review at 6 months and a year. A periapical radiograph for crestal bone analysis and an Implant stability quotient by resonance frequency analysis (ISQ) analysis were taken at baseline and the reviews. RESULTS: No statistically significant differences were found in the Implant stability quotient by resonance frequency analysis and Marginal Bone Loss in the four types of implants. The ISQ increased from the moment of insertion of the implant until the revision to the year, showing an increase of the stability implant, being this increasing less between the 6 months and the year. CONCLUSIONS: Differences in the design of the four implants tested in this study did not show statistically significant differences in any of the variables studied, so the implant design does not influence implant stability and marginal bone loss in the first year after placement. |
2018 |
M., Luna-Oliva Serrera-Figallo Torres-Lagares Rizo-Gorrita I M A D Superficial Characteristics of Titanium after Treatment of Chorreated Surface, Passive Acid, and Decontamination with Argon Plasma Artículo de revista J Funct Biomater., 9 (4), pp. pii: E71, 2018. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{Rizo-Gorrita2018b, title = {Superficial Characteristics of Titanium after Treatment of Chorreated Surface, Passive Acid, and Decontamination with Argon Plasma}, author = {Luna-Oliva Serrera-Figallo Torres-Lagares I M A D Rizo-Gorrita M.}, url = {https://www.ncbi.nlm.nih.gov/pmc?term=30544972[PMID]&report=imagesdocsum}, doi = {10.3390/jfb9040071}, year = {2018}, date = {2018-12-01}, journal = {J Funct Biomater.}, volume = {9}, number = {4}, pages = {pii: E71}, abstract = {1) Background. Titanium is characterized by its biocompatibility, resistance to maximum stress, and fatigue and non-toxicity. The composition, surface structure, and roughness of titanium have a key and direct influence on the osseointegration processes when it is used in the form of dental implants. The objective of the present study is to characterize, at chemical, superficial, and biological levels, the result of the application of the sandblasted with large-grit and acid-etched (SLA) treatment consisting of coarse-grained and double-passivated acid blasting with subsequent decontamination with argon plasma on the surface of titanium implants type IV. (2) Methods. Four Oxtein® dental implants (Zaragoza, Spain) were investigated with the following coding: Code L63713T (titanium grade IV, 3.75 mm in diameter, and 13 mm in length). The surface of the implants was SLA type obtained from coarse-grained, double passivated acid, and decontaminated with argon plasma. The samples were in their sealed packages and were opened in our laboratory. The X-ray photoelectron spectroscopy (XPS) technique was used to characterize the chemical composition of the surface, and the scanning electronic microscope (SEM) technique was used to perform topographic surface evaluation. Cell cultures were also performed on both surfaces. (3) Results. The superficial chemical analysis of the studied samples presented the following components, approximately, expressed in atomic percentage: O: 39%; Ti: 18%; C: 39%; N: 2%; and Si: 1%. In the same way, the topographic analysis values were obtained in the evaluated roughness parameters: Ra: 1.5 μm ± 0.02%; Rq: 1.31 μm ± 0.33; Rz: 8.98 μm ± 0.73; Rp: 5.12 μm ± 0.48; Rv: 3.76 μm ± 0.51; and Rc: 4.92 μm ± 0.24. At a biological level, the expression of osteocalcin was higher (p < 0.05) on the micro-rough surface compared to that machined at 48 and 96 h of culture. (4) Conclusions. The data obtained in our study indicate that the total carbon content, the relative concentration of titanium, and the roughness of the treatment performed on the implants are in agreement with those found in the literature. Further, the roughness of the treatment performed on the implants throws a spongy, three-dimensional surface suitable for bone growth on it. The biological results found are compatible with the clinical use of the surface tested.}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } 1) Background. Titanium is characterized by its biocompatibility, resistance to maximum stress, and fatigue and non-toxicity. The composition, surface structure, and roughness of titanium have a key and direct influence on the osseointegration processes when it is used in the form of dental implants. The objective of the present study is to characterize, at chemical, superficial, and biological levels, the result of the application of the sandblasted with large-grit and acid-etched (SLA) treatment consisting of coarse-grained and double-passivated acid blasting with subsequent decontamination with argon plasma on the surface of titanium implants type IV. (2) Methods. Four Oxtein® dental implants (Zaragoza, Spain) were investigated with the following coding: Code L63713T (titanium grade IV, 3.75 mm in diameter, and 13 mm in length). The surface of the implants was SLA type obtained from coarse-grained, double passivated acid, and decontaminated with argon plasma. The samples were in their sealed packages and were opened in our laboratory. The X-ray photoelectron spectroscopy (XPS) technique was used to characterize the chemical composition of the surface, and the scanning electronic microscope (SEM) technique was used to perform topographic surface evaluation. Cell cultures were also performed on both surfaces. (3) Results. The superficial chemical analysis of the studied samples presented the following components, approximately, expressed in atomic percentage: O: 39%; Ti: 18%; C: 39%; N: 2%; and Si: 1%. In the same way, the topographic analysis values were obtained in the evaluated roughness parameters: Ra: 1.5 μm ± 0.02%; Rq: 1.31 μm ± 0.33; Rz: 8.98 μm ± 0.73; Rp: 5.12 μm ± 0.48; Rv: 3.76 μm ± 0.51; and Rc: 4.92 μm ± 0.24. At a biological level, the expression of osteocalcin was higher (p < 0.05) on the micro-rough surface compared to that machined at 48 and 96 h of culture. (4) Conclusions. The data obtained in our study indicate that the total carbon content, the relative concentration of titanium, and the roughness of the treatment performed on the implants are in agreement with those found in the literature. Further, the roughness of the treatment performed on the implants throws a spongy, three-dimensional surface suitable for bone growth on it. The biological results found are compatible with the clinical use of the surface tested. |
M., Serrera-Figallo Hita-Iglesias Castillo-Oyagüe Casar-Espinosa Gutiérrez-Corrales Gutiérrez-Perez Torres-Lagares Menéndez-Collar M A P R J C A J L D Straight and tilted implants for supporting screw-retained full-arch dental prostheses in atrophic maxillae: A 2-year prospective study Artículo de revista Med Oral Patol Oral Cir Bucal., 23 (6), pp. e733-e741, 2018. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{Menéndez-Collar2018, title = {Straight and tilted implants for supporting screw-retained full-arch dental prostheses in atrophic maxillae: A 2-year prospective study}, author = {Serrera-Figallo Hita-Iglesias Castillo-Oyagüe Casar-Espinosa Gutiérrez-Corrales Gutiérrez-Perez Torres-Lagares M A P R J C A J L D Menéndez-Collar M.}, doi = {10.4317/medoral.22459}, year = {2018}, date = {2018-11-01}, journal = {Med Oral Patol Oral Cir Bucal.}, volume = {23}, number = {6}, pages = {e733-e741}, abstract = {BACKGROUND: To evaluate, over a 2-year period, the treatment outcomes for maxillary full-arch fixed dental prostheses (FDPs) supported by a combination of both tilted and axially-placed implants and to compare the marginal bone loss (MBL) and implant survival rates (SR) between tilted and axial implants. MATERIAL AND METHODS: A retrospective study has been carried out. Thirty-two patients (16 males and 16 females) treated with maxillary full-arch FDPs were included in this retrospective study. A total of 187 implants were inserted to rehabilitate the fully edentulous maxillary arches: 36% of them were tilted (T group}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } BACKGROUND: To evaluate, over a 2-year period, the treatment outcomes for maxillary full-arch fixed dental prostheses (FDPs) supported by a combination of both tilted and axially-placed implants and to compare the marginal bone loss (MBL) and implant survival rates (SR) between tilted and axial implants. MATERIAL AND METHODS: A retrospective study has been carried out. Thirty-two patients (16 males and 16 females) treated with maxillary full-arch FDPs were included in this retrospective study. A total of 187 implants were inserted to rehabilitate the fully edentulous maxillary arches: 36% of them were tilted (T group |
A., Navarro-Suárez Diosdado-Cano Azcárate-Velazquez Bargiela-Pérez Serrera-Figallo Torres-Lagares Gutiérrez-Pérez Coello-Gómez S J M F P M A D J L Postoperative effects on lower third molars of using mouthwashes with super-oxidized solution versus 0.2% chlorhexidine gel: A randomized double-blind trial Artículo de revista Med Oral Patol Oral Cir Bucal., 23 (6), pp. e716-e722, 2018. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{Coello-Gómez2018, title = {Postoperative effects on lower third molars of using mouthwashes with super-oxidized solution versus 0.2% chlorhexidine gel: A randomized double-blind trial}, author = {Navarro-Suárez Diosdado-Cano Azcárate-Velazquez Bargiela-Pérez Serrera-Figallo Torres-Lagares Gutiérrez-Pérez S J M F P M A D J L Coello-Gómez A.}, url = {https://www.ncbi.nlm.nih.gov/pmc?term=30341268[PMID]&report=imagesdocsum}, doi = {10.4317/medoral.22622}, year = {2018}, date = {2018-11-01}, journal = {Med Oral Patol Oral Cir Bucal.}, volume = {23}, number = {6}, pages = {e716-e722}, abstract = {BACKGROUND: The main objective of the present study is to evaluate the effects and possible benefits with regard to the postoperative period of lower third molar extractions, comparing the intraalveolar application of a bioadhesive gel of 0.2% chlorhexidine (CHX) to the use of a mouthwash with a super-oxidized solution, (SOS) Dermacyn® Wound Care (Oculus Innovative Sciences lnc., California, USA). MATERIAL AND METHODS: A randomized double-blind study was carried out in 20 patients with a split-mouth design, with a total of 40 extractions of symmetrically impacted bilateral lower third molars. Patients were divided into two groups, a control group (C = 20) and an experimental group (D = 20). Any infectious complications, wound healing, plaque accumulation in the stitches, and presence of trismus and inflammation were evaluated using the distance between different facial points, at three, eight, and fifteen days after extraction. Pain, swelling, and amount of analgesics taken were evaluated using the VAS scale throughout the 15 days following extraction. Tolerance to treatment was evaluated using a verbal scale. Results were statistically compared using the Student's t- and chi-squared tests. RESULTS: No statistically significant differences were found between the two groups with regard to infectious complications, swelling, or wound healing. Use of analgesics and self-reported pain levels were slightly lower in the experimental group than in the control group during days 6 and 7 of the study (p < 0.05). The global treatment tolerance was satisfactory and similar in both groups. CONCLUSIONS: Both CHX and SOS are effective at improving the postoperative period after extraction of lower third molars.}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } BACKGROUND: The main objective of the present study is to evaluate the effects and possible benefits with regard to the postoperative period of lower third molar extractions, comparing the intraalveolar application of a bioadhesive gel of 0.2% chlorhexidine (CHX) to the use of a mouthwash with a super-oxidized solution, (SOS) Dermacyn® Wound Care (Oculus Innovative Sciences lnc., California, USA). MATERIAL AND METHODS: A randomized double-blind study was carried out in 20 patients with a split-mouth design, with a total of 40 extractions of symmetrically impacted bilateral lower third molars. Patients were divided into two groups, a control group (C = 20) and an experimental group (D = 20). Any infectious complications, wound healing, plaque accumulation in the stitches, and presence of trismus and inflammation were evaluated using the distance between different facial points, at three, eight, and fifteen days after extraction. Pain, swelling, and amount of analgesics taken were evaluated using the VAS scale throughout the 15 days following extraction. Tolerance to treatment was evaluated using a verbal scale. Results were statistically compared using the Student's t- and chi-squared tests. RESULTS: No statistically significant differences were found between the two groups with regard to infectious complications, swelling, or wound healing. Use of analgesics and self-reported pain levels were slightly lower in the experimental group than in the control group during days 6 and 7 of the study (p < 0.05). The global treatment tolerance was satisfactory and similar in both groups. CONCLUSIONS: Both CHX and SOS are effective at improving the postoperative period after extraction of lower third molars. |
F., Oliveros-López Fernández-Olavarría Serrera-Figallo Gutiérrez-Corrales Torres-Lagares Gutiérrez-Pérez Iglesias-Martín L G A M A A D J L Advantages of surgical simulation in the surgical reconstruction of oncological patients Artículo de revista Med Oral Patol Oral Cir Bucal., 23 (5), pp. e596-e601, 2018. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{Iglesias-Martín2018, title = {Advantages of surgical simulation in the surgical reconstruction of oncological patients}, author = {Oliveros-López Fernández-Olavarría Serrera-Figallo Gutiérrez-Corrales Torres-Lagares Gutiérrez-Pérez L G A M A A D J L Iglesias-Martín F.}, url = {https://www.ncbi.nlm.nih.gov/pmc?term=30148473[PMID]&report=imagesdocsum}, doi = {10.4317/medoral.22336}, year = {2018}, date = {2018-09-01}, journal = {Med Oral Patol Oral Cir Bucal.}, volume = {23}, number = {5}, pages = {e596-e601}, abstract = {BACKGROUND: Stereolithography, which consists of computer-aided designed/computer-aided manufactured (CAD-CAM) and computer simulations, is a manufacturing technologies used for the production of definitive models and prototypes printed in three dimensions, and is widely used in Oral and Maxillofacial Surgery. Surgical procedures using models made by these technologies offer several advantages. MATERIALS AND METHODS: This article describes three clinical cases of our experiences with patients diagnosed with squamous cell carcinoma and mandibular osteosarcoma, who underwent surgical removal of the lesions and subsequent mandibular reconstruction with a free fibula graft using surgical guides. RESULTS: In all three clinical cases, surgical guides were used for the mandibular osteotomy, fibula osteotomy, and graft placement in the recipient area. DISCUSSION: Surgical guidelines are useful for improving the accuracy of surgical interventions and are appropriate for many types of resection and mandibular reconstruction.}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } BACKGROUND: Stereolithography, which consists of computer-aided designed/computer-aided manufactured (CAD-CAM) and computer simulations, is a manufacturing technologies used for the production of definitive models and prototypes printed in three dimensions, and is widely used in Oral and Maxillofacial Surgery. Surgical procedures using models made by these technologies offer several advantages. MATERIALS AND METHODS: This article describes three clinical cases of our experiences with patients diagnosed with squamous cell carcinoma and mandibular osteosarcoma, who underwent surgical removal of the lesions and subsequent mandibular reconstruction with a free fibula graft using surgical guides. RESULTS: In all three clinical cases, surgical guides were used for the mandibular osteotomy, fibula osteotomy, and graft placement in the recipient area. DISCUSSION: Surgical guidelines are useful for improving the accuracy of surgical interventions and are appropriate for many types of resection and mandibular reconstruction. |
M., Luna-Oliva Serrera-Figallo Gutiérrez-Pérez Torres-Lagares Rizo-Gorrita I M Á J L D Comparison of Cytomorphometry and Early Cell Response of Human Gingival Fibroblast (HGFs) between Zirconium and New Zirconia-Reinforced Lithium Silicate Ceramics (ZLS) Artículo de revista Int J Mol Sci., 19 (9), pp. pii: E2718, 2018. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{Rizo-Gorrita2018b, title = {Comparison of Cytomorphometry and Early Cell Response of Human Gingival Fibroblast (HGFs) between Zirconium and New Zirconia-Reinforced Lithium Silicate Ceramics (ZLS)}, author = {Luna-Oliva Serrera-Figallo Gutiérrez-Pérez Torres-Lagares I M Á J L D Rizo-Gorrita M.}, url = {https://www.ncbi.nlm.nih.gov/pmc?term=30208663[PMID]&report=imagesdocsum}, doi = {10.3390/ijms19092718}, year = {2018}, date = {2018-09-01}, journal = {Int J Mol Sci.}, volume = {19}, number = {9}, pages = {pii: E2718}, abstract = {New zirconia-reinforced lithium silicate ceramics (ZLS) could be a viable alternative to zirconium (Y-TZP) in the manufacture of implantological abutments-especially in aesthetic cases-due to its good mechanical, optical, and biocompatibility properties. Although there are several studies on the ZLS mechanical properties, there are no studies regarding proliferation, spreading, or cytomorphometry. We designed the present study which compares the surface, cellular proliferation, and cellular morphology between Y-TZP (Vita YZ® T [Vita Zahnfabrik (Postfach, Germany)]) and ZLS (Celtra® Duo [Degudent (Hanau-Wolfgang, Germany)]). The surface characterization was performed with energy dispersive spectroscopy (EDS), scanning electron microscopy (SEM), and optical profilometry. Human gingival fibroblasts (HGFs) were subsequently cultured on both materials and early cellular response and cell morphology were compared through nuclear and cytoskeletal measurement parameters using confocal microscopy. The results showed greater proliferation and spreading on the surface of Y-TZP. This could indicate that Y-TZP continues to be a gold standard in terms of transgingival implant material: Nevertheless, more in vitro and in vivo research is necessary to confirm the results obtained in this study.}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } New zirconia-reinforced lithium silicate ceramics (ZLS) could be a viable alternative to zirconium (Y-TZP) in the manufacture of implantological abutments-especially in aesthetic cases-due to its good mechanical, optical, and biocompatibility properties. Although there are several studies on the ZLS mechanical properties, there are no studies regarding proliferation, spreading, or cytomorphometry. We designed the present study which compares the surface, cellular proliferation, and cellular morphology between Y-TZP (Vita YZ® T [Vita Zahnfabrik (Postfach, Germany)]) and ZLS (Celtra® Duo [Degudent (Hanau-Wolfgang, Germany)]). The surface characterization was performed with energy dispersive spectroscopy (EDS), scanning electron microscopy (SEM), and optical profilometry. Human gingival fibroblasts (HGFs) were subsequently cultured on both materials and early cellular response and cell morphology were compared through nuclear and cytoskeletal measurement parameters using confocal microscopy. The results showed greater proliferation and spreading on the surface of Y-TZP. This could indicate that Y-TZP continues to be a gold standard in terms of transgingival implant material: Nevertheless, more in vitro and in vivo research is necessary to confirm the results obtained in this study. |
J., Oliveros-Lopez Fernandez-Olavarria Torres-Lagares Serrera-Figallo Gutierrez-Corrales Gutierrez-Perez Nunez-Aguilar L G A D M A A J L Influence of dental treatment in place on quality of life in oral cancer patients undergoing chemoradiotherapy Artículo de revista Med Oral Patol Oral Cir Bucal., 23 (4), pp. e498-e505, 2018. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{Nunez-Aguilar2018b, title = {Influence of dental treatment in place on quality of life in oral cancer patients undergoing chemoradiotherapy}, author = {Oliveros-Lopez Fernandez-Olavarria Torres-Lagares Serrera-Figallo Gutierrez-Corrales Gutierrez-Perez L G A D M A A J L Nunez-Aguilar J.}, url = {https://www.ncbi.nlm.nih.gov/pmc?term=29924760[PMID]&report=imagesdocsum}, doi = {10.4317/medoral.22353}, year = {2018}, date = {2018-07-01}, journal = {Med Oral Patol Oral Cir Bucal.}, volume = {23}, number = {4}, pages = {e498-e505}, abstract = {BACKGROUND: This study aims to assess, in the population of patients with oral cancer treatment, the influence on the quality of life of two protocols of dental treatment: not ruled hospital treatment versus ruled hospital treatment. Matrial and Methods: A quasi-experimental approach justified on ethical grounds was used. A total of 41 patients were included in the control group (not ruled treatment outpatient health center) and 40 in the experimental group (ruled hospital treatment). A total of 14 questions to both groups were conducted in three stages: before starting cancer treatment, during treatment and after treatment. the proportions of positive responses in groups and different times were compared using the chi-square test. RESULTS: Based on similar situations during cancer treatment were identified as six issues favorable to the experimental group difference. This number rose to nine after finishing oncological treatment. CONCLUSIONS: From our data we can confirm that planned dental treatment performed during the oral cancer treatment produces an improvement in the quality of life in patients with oral cancer.}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } BACKGROUND: This study aims to assess, in the population of patients with oral cancer treatment, the influence on the quality of life of two protocols of dental treatment: not ruled hospital treatment versus ruled hospital treatment. Matrial and Methods: A quasi-experimental approach justified on ethical grounds was used. A total of 41 patients were included in the control group (not ruled treatment outpatient health center) and 40 in the experimental group (ruled hospital treatment). A total of 14 questions to both groups were conducted in three stages: before starting cancer treatment, during treatment and after treatment. the proportions of positive responses in groups and different times were compared using the chi-square test. RESULTS: Based on similar situations during cancer treatment were identified as six issues favorable to the experimental group difference. This number rose to nine after finishing oncological treatment. CONCLUSIONS: From our data we can confirm that planned dental treatment performed during the oral cancer treatment produces an improvement in the quality of life in patients with oral cancer. |
F., Castellanos-Cosano Pachón-Ibañez Serrera-Figallo Gutiérrez-Pérez Torres-Lagares Marín-Conde L J M A J L D Photobiomodulation with low-level laser therapy reduces oral mucositis caused by head and neck radio-chemotherapy: prospective randomized controlled trial Artículo de revista Int J Oral Maxillofac Surg., 48 (7), pp. 917-923, 2018. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{Marín-Conde2018, title = {Photobiomodulation with low-level laser therapy reduces oral mucositis caused by head and neck radio-chemotherapy: prospective randomized controlled trial}, author = {Castellanos-Cosano Pachón-Ibañez Serrera-Figallo Gutiérrez-Pérez Torres-Lagares L J M A J L D Marín-Conde F.}, doi = {10.1016/j.ijom.2018.12.006}, year = {2018}, date = {2018-07-01}, journal = {Int J Oral Maxillofac Surg.}, volume = {48}, number = {7}, pages = {917-923}, abstract = {The objective of this study was to assess the effectiveness of photobiomodulation with low-level laser therapy (LLLT) as a preventive and therapeutic procedure for the treatment of oral and oropharyngeal mucositis caused by radio-chemotherapy in patients diagnosed with oral squamous cell carcinoma (SCC). An experimental, prospective, double-blind, randomized controlled study was conducted involving patients diagnosed with oral SCC undergoing oncological treatment. The variables analyzed included grade, appearance, and remission of mucositis. A final sample of 26 patients was included: 11 (42.3%) in the study group and 15 (57.7%) in the control group; their average age was 60.89±9.99years. Statistically significant differences between the groups were observed from week 5 of oncological treatment; 72.7% of the laser group showed normal mucosa (mucositis grade 0), while in the control group, 20.0% showed grade 0 mucositis and 40.0% showed grade 2 mucositis (P<0.01). No statistically significant difference between the groups was found regarding the application or use of medication throughout the study period (P>0.05). The tolerance evaluation did not show any statistically significant difference between the groups regarding the occurrence of side effects or adverse events during the trial (P>0.05). Photobiomodulation with LLLT reduces the incidence and severity of mucositis in patients treated with radiotherapy±chemotherapy.}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } The objective of this study was to assess the effectiveness of photobiomodulation with low-level laser therapy (LLLT) as a preventive and therapeutic procedure for the treatment of oral and oropharyngeal mucositis caused by radio-chemotherapy in patients diagnosed with oral squamous cell carcinoma (SCC). An experimental, prospective, double-blind, randomized controlled study was conducted involving patients diagnosed with oral SCC undergoing oncological treatment. The variables analyzed included grade, appearance, and remission of mucositis. A final sample of 26 patients was included: 11 (42.3%) in the study group and 15 (57.7%) in the control group; their average age was 60.89±9.99years. Statistically significant differences between the groups were observed from week 5 of oncological treatment; 72.7% of the laser group showed normal mucosa (mucositis grade 0), while in the control group, 20.0% showed grade 0 mucositis and 40.0% showed grade 2 mucositis (P<0.01). No statistically significant difference between the groups was found regarding the application or use of medication throughout the study period (P>0.05). The tolerance evaluation did not show any statistically significant difference between the groups regarding the occurrence of side effects or adverse events during the trial (P>0.05). Photobiomodulation with LLLT reduces the incidence and severity of mucositis in patients treated with radiotherapy±chemotherapy. |
R., Castellanos-Cosano Serrera-Figallo Gutiérrez-Corrales Castillo-Oyague Gutiérrez-Perez Torres-Lagares Flores-Ruiz L M A A R J L D Evolution of oral neoplasm in an andalusian population (Spain) Artículo de revista Med Oral Patol Oral Cir Bucal., 23 (1), pp. e86-e91, 2018. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{Flores-Ruiz2018, title = {Evolution of oral neoplasm in an andalusian population (Spain)}, author = {Castellanos-Cosano Serrera-Figallo Gutiérrez-Corrales Castillo-Oyague Gutiérrez-Perez Torres-Lagares L M A A R J L D Flores-Ruiz R.}, doi = {10.4317/medoral.21839}, year = {2018}, date = {2018-06-01}, journal = {Med Oral Patol Oral Cir Bucal.}, volume = {23}, number = {1}, pages = {e86-e91}, abstract = {BACKGROUND: Head and neck cancer are one of the most common neoplasm pathologies in humans. The aim of this study was to analyze the type, characteristics, treatment and evolution of oral neoplasm or precancerous lesion in a sample of Andalusian population (Spain) derived from the Oncology Rehabilitation Hospital Unit during a period of 20 years. MATERIAL AND METHODS: A retrospective descriptive study was carried out during the years 1991 and 2011 analyzing the type, characteristics, treatment and follow-up of oral neoplasm in the Oral and Maxillofacial Surgery Unit of the Universitary Hospital Virgen del Rocio. The inclusion criteria were patients whose underlying pathology was any type of benign or malignant neoplasm or presence of precancerous lesion that, after treatment, had been referred to the Prosthetic Rehabilitation Unit. RESULTS: Of the initial analyzed sample of 60 patients, only 45 patients met the inclusion criteria. Of the final sample analyzed, 31 subjects were men (68.9%) and 14 women (31.1%) (p = 0.0169). The mean age of the sample was 57 years ± 13.83, been more frequently in older people with more than 50 years (73.3%) (p = 0.0169). The most common type of neoplasm was epidermoid carcinoma (64.4%). The site most frequently found in squamous cell carcinoma was the floor of the mouth (31%). The most frequent treatment modality was surgery with postoperative radiotherapy (42.2%). All patients had a minimum follow-up of 5 years, and a recurrence in this period was identified in 11.1% of the sample. Multivariate logistic regression showed a statistically significant association for the variables age (p = 0.0063) and smoking (p = 0.0434). CONCLUSIONS: Epidermoid carcinoma is the most frequent tumor in the oral cavity, where increase age and smoking are confirmed as associated risk factors.}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } BACKGROUND: Head and neck cancer are one of the most common neoplasm pathologies in humans. The aim of this study was to analyze the type, characteristics, treatment and evolution of oral neoplasm or precancerous lesion in a sample of Andalusian population (Spain) derived from the Oncology Rehabilitation Hospital Unit during a period of 20 years. MATERIAL AND METHODS: A retrospective descriptive study was carried out during the years 1991 and 2011 analyzing the type, characteristics, treatment and follow-up of oral neoplasm in the Oral and Maxillofacial Surgery Unit of the Universitary Hospital Virgen del Rocio. The inclusion criteria were patients whose underlying pathology was any type of benign or malignant neoplasm or presence of precancerous lesion that, after treatment, had been referred to the Prosthetic Rehabilitation Unit. RESULTS: Of the initial analyzed sample of 60 patients, only 45 patients met the inclusion criteria. Of the final sample analyzed, 31 subjects were men (68.9%) and 14 women (31.1%) (p = 0.0169). The mean age of the sample was 57 years ± 13.83, been more frequently in older people with more than 50 years (73.3%) (p = 0.0169). The most common type of neoplasm was epidermoid carcinoma (64.4%). The site most frequently found in squamous cell carcinoma was the floor of the mouth (31%). The most frequent treatment modality was surgery with postoperative radiotherapy (42.2%). All patients had a minimum follow-up of 5 years, and a recurrence in this period was identified in 11.1% of the sample. Multivariate logistic regression showed a statistically significant association for the variables age (p = 0.0063) and smoking (p = 0.0434). CONCLUSIONS: Epidermoid carcinoma is the most frequent tumor in the oral cavity, where increase age and smoking are confirmed as associated risk factors. |
P., González-Merchan Díaz-Sanchez Serrera-Figallo Volland Joergens Gutiérrez-Perez Torres-Lagares Bargiela-Pérez J R M A G M J L D Prospective study of the 532 nm laser (KTP) versus diode laser 980 nm in the resection of hyperplastic lesions of the oral cavity Artículo de revista Med Oral Patol Oral Cir Bucal., 23 (1), pp. e78-e85, 2018. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{Bargiela-Pérez2018, title = {Prospective study of the 532 nm laser (KTP) versus diode laser 980 nm in the resection of hyperplastic lesions of the oral cavity}, author = {González-Merchan Díaz-Sanchez Serrera-Figallo Volland Joergens Gutiérrez-Perez Torres-Lagares J R M A G M J L D Bargiela-Pérez P.}, url = {https://www.ncbi.nlm.nih.gov/pmc?term=29274158[PMID]&report=imagesdocsum}, doi = {10.4317/medoral.21812}, year = {2018}, date = {2018-06-01}, journal = {Med Oral Patol Oral Cir Bucal.}, volume = {23}, number = {1}, pages = {e78-e85}, abstract = {BACKGROUND: The aim of this study is to evaluate the resection of hyperplastic lesions on the buccal mucosa comparing the 532nm laser (KTP), versus diode 980nm laser, considering pain, scarring, inflammation and drug consumption that occurred postoperatively with each lasers. MATERIAL AND METHODS: A prospective study of consecutive series of 20 patients in two groups that presents hyperplastic lesions on the buccal mucosa. The choice of the KTP laser or diode 980nm laser for the surgery was made randomly. The power used was 1.5W in both groups in a continuous wave mode with a 320 μm optical fiber. Parameters of pain, scarring, inflammation and consumption of drugs were recorded by a Numerical Rating Scale and evaluated postoperatively. These recordings were made the day of the surgery, 24 hours after, 14 and 28 days after. RESULTS: Pain and inflammation was light - moderate. The consumption of paracetamol was somewhat higher in the diode 980nm laser versus the KTP laser after 24 hours, although data was not statistically significant; significant differences were found after 28 days in regards to pain (p = 0.023) and inflammation (p = 0.023), but always in the absence parameter so we find no pain in both lasers. Scarring in the two types of laser showed no differences along the visits, with not detected scar retractable. CONCLUSIONS: Although there is a slight histological difference regarding the KTP laser in the oral soft tissues for clinical use, both wavelengths are very suitable for excision of oral fibroma.}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } BACKGROUND: The aim of this study is to evaluate the resection of hyperplastic lesions on the buccal mucosa comparing the 532nm laser (KTP), versus diode 980nm laser, considering pain, scarring, inflammation and drug consumption that occurred postoperatively with each lasers. MATERIAL AND METHODS: A prospective study of consecutive series of 20 patients in two groups that presents hyperplastic lesions on the buccal mucosa. The choice of the KTP laser or diode 980nm laser for the surgery was made randomly. The power used was 1.5W in both groups in a continuous wave mode with a 320 μm optical fiber. Parameters of pain, scarring, inflammation and consumption of drugs were recorded by a Numerical Rating Scale and evaluated postoperatively. These recordings were made the day of the surgery, 24 hours after, 14 and 28 days after. RESULTS: Pain and inflammation was light - moderate. The consumption of paracetamol was somewhat higher in the diode 980nm laser versus the KTP laser after 24 hours, although data was not statistically significant; significant differences were found after 28 days in regards to pain (p = 0.023) and inflammation (p = 0.023), but always in the absence parameter so we find no pain in both lasers. Scarring in the two types of laser showed no differences along the visits, with not detected scar retractable. CONCLUSIONS: Although there is a slight histological difference regarding the KTP laser in the oral soft tissues for clinical use, both wavelengths are very suitable for excision of oral fibroma. |
P., Torres-Lagares Segura-Egea Serrera-Figallo Gutierrez-Perez Castillo-Dali Montero-Miralles D J J M Á J L G Comparative study of debris and smear layer removal with EDTA and Er,Cr:YSGG laser Artículo de revista J Clin Exp Dent., 10 (6), pp. :e598-e602, 2018. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{Montero-Miralles2018, title = {Comparative study of debris and smear layer removal with EDTA and Er,Cr:YSGG laser}, author = {Torres-Lagares Segura-Egea Serrera-Figallo Gutierrez-Perez Castillo-Dali D J J M Á J L G Montero-Miralles P.}, url = {https://www.ncbi.nlm.nih.gov/pmc?term=29930779[PMID]&report=imagesdocsum}, doi = {10.4317/jced.54936}, year = {2018}, date = {2018-06-01}, journal = {J Clin Exp Dent.}, volume = {10}, number = {6}, pages = {:e598-e602}, abstract = {BACKGROUND: To evaluate in vitro, the ability in removing debris and Smear Layer of 17% EDTA and Er,Cr:YSGG laser. MATERIAL AND METHODS: 58 unirradicular teeth were instrumented with MTwo® and divided into 3 groups according to irrigation protocol: 17%EDTA, laser and a combination of 17%EDTA and laser. All samples were analyzed in the apical and middle third with Scanning Electron Microscope. The Chi-cuadrado and McNemar tests were used to determine the statistical analysis and data processing and analysis was performed with the statistical package StatGraphics Centurion XVI. RESULTS: Debris analysis showed statistical significant differences when compared EDTA vs laser and EDTA vs EDTA+laser in the middle third. The Smear Layer removal showed statistical significant differences in the middle third when compared EDTA vs laser and EDTA vs EDTA+laser. CONCLUSIONS: Laser showed a greater cleaning capacity than EDTA in the middle third; the cleanliness was even better when combined laser with EDTA, so the effect is accumulative. Key words:Root canal treatment, Smear Layer, Er,Cr:YSGG laser, debridement.}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } BACKGROUND: To evaluate in vitro, the ability in removing debris and Smear Layer of 17% EDTA and Er,Cr:YSGG laser. MATERIAL AND METHODS: 58 unirradicular teeth were instrumented with MTwo® and divided into 3 groups according to irrigation protocol: 17%EDTA, laser and a combination of 17%EDTA and laser. All samples were analyzed in the apical and middle third with Scanning Electron Microscope. The Chi-cuadrado and McNemar tests were used to determine the statistical analysis and data processing and analysis was performed with the statistical package StatGraphics Centurion XVI. RESULTS: Debris analysis showed statistical significant differences when compared EDTA vs laser and EDTA vs EDTA+laser in the middle third. The Smear Layer removal showed statistical significant differences in the middle third when compared EDTA vs laser and EDTA vs EDTA+laser. CONCLUSIONS: Laser showed a greater cleaning capacity than EDTA in the middle third; the cleanliness was even better when combined laser with EDTA, so the effect is accumulative. Key words:Root canal treatment, Smear Layer, Er,Cr:YSGG laser, debridement. |
R., Castellanos-Cosano Serrera-Figallo Cano-Díaz Torres-Lagares Gutiérrez-Pérez Flores-Ruiz L M A E D J L Implant survival in patients with oral cancer: A 5-year follow-up. Artículo de revista J Clin Exp Dent., 10 (6), pp. e603-e609, 2018. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{Flores-Ruiz2018b, title = {Implant survival in patients with oral cancer: A 5-year follow-up.}, author = {Castellanos-Cosano Serrera-Figallo Cano-Díaz Torres-Lagares Gutiérrez-Pérez L M A E D J L Flores-Ruiz R.}, doi = {10.4317/jced.54937}, year = {2018}, date = {2018-06-01}, journal = {J Clin Exp Dent.}, volume = {10}, number = {6}, pages = {e603-e609}, abstract = {BACKGROUND: To evaluate the evolution of patients rehabilitated with endosseous implants after oral cancer treatment. MATERIAL AND METHODS: An observational retrospective study was carried out between 1991 and 2011 with a sample consisting of patients with oral cancer who had been referred for rehabilitation to the Prosthetics Rehabilitation Unit from the Oral and Maxillofacial Surgery Unit of the Virgen del Rocío University Hospital. All these patients have overcome oral cancer, and have a five-year follow-up after their oral rehabilitation. Age, sex, smoking habits, oral pathology, type of treatment of oral pathology, edentulism, receptor bone, prosthetic rehabilitation, timeouts, working time and evolution were studied. SPSS Statistics was used for statistical analysis of the variables studied. A chi-square test centered on the survival rate of implants placed in relation to the other recorded variables was performed. RESULTS: 17 patients were treated for cancer and rehabilitated with implant prosthetics, with a total of 106 implants placed. 32% were partially edentulous patients (4 patients), and 68.2% were completely edentulous patients (13 patients). An implant survival rate of 87.7% was observed at 5 years. In the upper maxilla, the survival rate was 79.2%, and in the mandible 93.7% (p = 0.03). 91 implants were placed in native receptor bones (85.8%), with only 15 implants placed in grafted receptor bone (14.2%). According to the type of receptor bone, in native receptor bones, 9 implants failed (90.1% of implant survival), while in grafted receptor bones, 4 implants failed (overall 73.3% implant survival rate) (p = 0.08). CONCLUSIONS: Although a high survival rate was obtained in this study (with lower survival rates seen in mandible and grafted bone), prospective long-term studies are needed to assess the relationship between radiotherapy doses and the time required for implant placement, prosthetic protocol used, and type of implants used in patients selected for prosthetic rehabilitation. Key words:Dental implant, oral cancer, survival.}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } BACKGROUND: To evaluate the evolution of patients rehabilitated with endosseous implants after oral cancer treatment. MATERIAL AND METHODS: An observational retrospective study was carried out between 1991 and 2011 with a sample consisting of patients with oral cancer who had been referred for rehabilitation to the Prosthetics Rehabilitation Unit from the Oral and Maxillofacial Surgery Unit of the Virgen del Rocío University Hospital. All these patients have overcome oral cancer, and have a five-year follow-up after their oral rehabilitation. Age, sex, smoking habits, oral pathology, type of treatment of oral pathology, edentulism, receptor bone, prosthetic rehabilitation, timeouts, working time and evolution were studied. SPSS Statistics was used for statistical analysis of the variables studied. A chi-square test centered on the survival rate of implants placed in relation to the other recorded variables was performed. RESULTS: 17 patients were treated for cancer and rehabilitated with implant prosthetics, with a total of 106 implants placed. 32% were partially edentulous patients (4 patients), and 68.2% were completely edentulous patients (13 patients). An implant survival rate of 87.7% was observed at 5 years. In the upper maxilla, the survival rate was 79.2%, and in the mandible 93.7% (p = 0.03). 91 implants were placed in native receptor bones (85.8%), with only 15 implants placed in grafted receptor bone (14.2%). According to the type of receptor bone, in native receptor bones, 9 implants failed (90.1% of implant survival), while in grafted receptor bones, 4 implants failed (overall 73.3% implant survival rate) (p = 0.08). CONCLUSIONS: Although a high survival rate was obtained in this study (with lower survival rates seen in mandible and grafted bone), prospective long-term studies are needed to assess the relationship between radiotherapy doses and the time required for implant placement, prosthetic protocol used, and type of implants used in patients selected for prosthetic rehabilitation. Key words:Dental implant, oral cancer, survival. |
C., Montoya-Salazar Torres-Lagares Gutierrez-Pérez Jimenez-Castellanos Torres-Sánchez V D J L E Satisfaction in complete denture wearers with and without adhesives: A randomized, crossover, double-blind clinical trial Artículo de revista J Clin Exp Dent., 10 (6), pp. e585-e590, 2018. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{Torres-Sánchez2018, title = {Satisfaction in complete denture wearers with and without adhesives: A randomized, crossover, double-blind clinical trial}, author = {Montoya-Salazar Torres-Lagares Gutierrez-Pérez Jimenez-Castellanos V D J L E Torres-Sánchez C.}, url = {https://www.ncbi.nlm.nih.gov/pmc?term=29946414[PMID]&report=imagesdocsum}, doi = {10.4317/jced.54871}, year = {2018}, date = {2018-06-01}, journal = {J Clin Exp Dent.}, volume = {10}, number = {6}, pages = {e585-e590}, abstract = {BACKGROUND: The purpose of this study was to compare the satisfaction of patients regarding retention, stability and accumulation of particles with a randomized, double-blind crossed method in users with complete dentures with and without adhesive. MATERIAL AND METHODS: Seventeen edentulous individuals were randomized and received new upper and lower complete dentures. After a period of adaptation, they participated in some masticatory tests and clinical revisions, after use the protheses with and without the use of two denture adhesives: Adhesive A (Fittydent, Fittydent International GmbH) and adhesive B (Corega, GlaxoSmithKline) at 0, 7 and 14 days. Satisfaction was measured immediately after each test through a survey using a VAS scale (0-10) and data were analyzed with McNemar's test with Bonferroni correction. RESULTS: The results showed significant differences (p<.01) between the study groups with adhesive A - B and the group without adhesive, but no significant differences were found between the two stickers for any of the variables studied. CONCLUSIONS: Complete denture adhesives significantly improved the satisfaction of patients because a better retention, stability and less accumulation of particles of the food substitute between the denture and the mucosa is obtained compared with non-use of complete denture adhesives. Key words:Complete dentures, patient satisfaction, denture adhesives, clinical trials.}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } BACKGROUND: The purpose of this study was to compare the satisfaction of patients regarding retention, stability and accumulation of particles with a randomized, double-blind crossed method in users with complete dentures with and without adhesive. MATERIAL AND METHODS: Seventeen edentulous individuals were randomized and received new upper and lower complete dentures. After a period of adaptation, they participated in some masticatory tests and clinical revisions, after use the protheses with and without the use of two denture adhesives: Adhesive A (Fittydent, Fittydent International GmbH) and adhesive B (Corega, GlaxoSmithKline) at 0, 7 and 14 days. Satisfaction was measured immediately after each test through a survey using a VAS scale (0-10) and data were analyzed with McNemar's test with Bonferroni correction. RESULTS: The results showed significant differences (p<.01) between the study groups with adhesive A - B and the group without adhesive, but no significant differences were found between the two stickers for any of the variables studied. CONCLUSIONS: Complete denture adhesives significantly improved the satisfaction of patients because a better retention, stability and less accumulation of particles of the food substitute between the denture and the mucosa is obtained compared with non-use of complete denture adhesives. Key words:Complete dentures, patient satisfaction, denture adhesives, clinical trials. |
D., Castellanos-Cosano Serrera-Figallo López-Santos Barranco Rodríguez-González-Elipe Gutierrez-Perez Torres-Lagares L M A C A A J L In Vitro Comparative Study of Oxygen Plasma Treated Poly(Lactic⁻Co⁻Glycolic) (PLGA) Membranes and Supported Nanostructured Oxides for Guided Bone Regeneration Processes Artículo de revista Materials (Basel)., 11 (5), pp. pii: E752, 2018. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{Torres-Lagares2018, title = {In Vitro Comparative Study of Oxygen Plasma Treated Poly(Lactic⁻Co⁻Glycolic) (PLGA) Membranes and Supported Nanostructured Oxides for Guided Bone Regeneration Processes}, author = {Castellanos-Cosano Serrera-Figallo López-Santos Barranco Rodríguez-González-Elipe Gutierrez-Perez L M A C A A J L Torres-Lagares D.}, url = {https://www.ncbi.nlm.nih.gov/pmc?term=29738457[PMID]&report=imagesdocsum}, doi = {10.3390/ma11050752}, year = {2018}, date = {2018-05-08}, journal = {Materials (Basel).}, volume = {11}, number = {5}, pages = {pii: E752}, abstract = {(1) Background: The use of physical barriers to prevent the invasion of gingival and connective tissue cells into bone cavities during the healing process is called guided bone regeneration. The objective of this in-vitro study was to compare the growth of human osteoblasts on Poly(Lactic⁻co⁻Glycolic) (PLGA) membranes modified with oxygen plasma and Hydroxyapatite (HA), silicon dioxide (SiO₂), and titanium dioxide (TiO₂) composite nanoparticles, respectively. (2) Methods: All the membranes received a common treatment with oxygen plasma and were subsequently treated with HA nanostructured coatings (n = 10), SiO₂ (n = 10) and TiO₂ (n = 10), respectively and a PLGA control membrane (n = 10). The assays were performed using the human osteoblast line MG-63 acquired from the Center for Scientific Instrumentation (CIC) from the University of Granada. The cell adhesion and the viability of the osteoblasts were analyzed by means of light-field microphotographs of each condition with the inverted microscope Axio Observer A1 (Carl Zeiss). For the determination of the mitochondrial energy balance, the MitoProbe™ JC-1 Assay Kit was employed. For the determination of cell growth and the morphology of adherent osteoblasts, two techniques were employed: staining with phalloidin-TRITC and staining with DAPI. (3) Results: The modified membranes that show osteoblasts with a morphology more similar to the control osteoblasts follow the order: PLGA/PO₂/HA > PLGA/PO₂/SiO₂ > PLGA/PO₂/TiO₂ > PLGA (p < 0.05). When analysing the cell viability, a higher percentage of viable cells bound to the membranes was observed as follows: PLGA/PO₂/SiO₂ > PLGA/PO₂/HA > PLGA/PO₂/TiO₂ > PLGA (p < 0.05), with a better energy balance of the cells adhered to the membranes PLGA/PO₂/HA and PLGA/PO₂/SiO₂. (4) Conclusion: The membrane in which osteoblasts show characteristics more similar to the control osteoblasts is the PLGA/PO₂/HA, followed by the PLGA/PO₂/SiO₂.}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } (1) Background: The use of physical barriers to prevent the invasion of gingival and connective tissue cells into bone cavities during the healing process is called guided bone regeneration. The objective of this in-vitro study was to compare the growth of human osteoblasts on Poly(Lactic⁻co⁻Glycolic) (PLGA) membranes modified with oxygen plasma and Hydroxyapatite (HA), silicon dioxide (SiO₂), and titanium dioxide (TiO₂) composite nanoparticles, respectively. (2) Methods: All the membranes received a common treatment with oxygen plasma and were subsequently treated with HA nanostructured coatings (n = 10), SiO₂ (n = 10) and TiO₂ (n = 10), respectively and a PLGA control membrane (n = 10). The assays were performed using the human osteoblast line MG-63 acquired from the Center for Scientific Instrumentation (CIC) from the University of Granada. The cell adhesion and the viability of the osteoblasts were analyzed by means of light-field microphotographs of each condition with the inverted microscope Axio Observer A1 (Carl Zeiss). For the determination of the mitochondrial energy balance, the MitoProbe™ JC-1 Assay Kit was employed. For the determination of cell growth and the morphology of adherent osteoblasts, two techniques were employed: staining with phalloidin-TRITC and staining with DAPI. (3) Results: The modified membranes that show osteoblasts with a morphology more similar to the control osteoblasts follow the order: PLGA/PO₂/HA > PLGA/PO₂/SiO₂ > PLGA/PO₂/TiO₂ > PLGA (p < 0.05). When analysing the cell viability, a higher percentage of viable cells bound to the membranes was observed as follows: PLGA/PO₂/SiO₂ > PLGA/PO₂/HA > PLGA/PO₂/TiO₂ > PLGA (p < 0.05), with a better energy balance of the cells adhered to the membranes PLGA/PO₂/HA and PLGA/PO₂/SiO₂. (4) Conclusion: The membrane in which osteoblasts show characteristics more similar to the control osteoblasts is the PLGA/PO₂/HA, followed by the PLGA/PO₂/SiO₂. |
R., Torres-Sanchez Mareque-Bueno Zufía-González Torres-Lagares Gutierrez-Pérez Gómez-Meda C S J D J L Papilla and pontic area regeneration in patient with gingival smile: A clinical case Artículo de revista J Clin Exp Dent., 10 (5), pp. e507-e512, 2018. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{Gómez-Meda2018, title = {Papilla and pontic area regeneration in patient with gingival smile: A clinical case}, author = {Torres-Sanchez Mareque-Bueno Zufía-González Torres-Lagares Gutierrez-Pérez C S J D J L Gómez-Meda R.}, url = {https://www.ncbi.nlm.nih.gov/pmc?term=29849978[PMID]&report=imagesdocsum}, doi = {10.4317/jced.54859}, year = {2018}, date = {2018-05-01}, journal = {J Clin Exp Dent.}, volume = {10}, number = {5}, pages = {e507-e512}, abstract = {PURPOSE: Connective tissue grafts are widely documented as a predictable technique for treating Miller Class I and II recessions, as well as procedures in which soft tissue augmentation is required for aesthetic reasons. This article aims to explore the resolution of a clinical case with this type of problema. CLINICAL CASE: This case describes a technique for reconstructing a pontic area and adjacent papilla by means of two consecutive connective tissue grafts. The first graft served to increase the amount of tissue in the horizontal direction, and the second promoted vertical reconstruction of the defect. RESULTS AND CONCLUSION: In cases with aesthetic requirements, restorative intervention may be able to mask tissue loss, but it can hardly achieve optimal aesthetic results. Periodontal plastic surgery techniques can be used to achieve that ideal result. The clinician must diagnose conditions in order to select correct treatment regimen for each individual case. Key words:Papilla, gingival smile, pontic, restorative dentistry.}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } PURPOSE: Connective tissue grafts are widely documented as a predictable technique for treating Miller Class I and II recessions, as well as procedures in which soft tissue augmentation is required for aesthetic reasons. This article aims to explore the resolution of a clinical case with this type of problema. CLINICAL CASE: This case describes a technique for reconstructing a pontic area and adjacent papilla by means of two consecutive connective tissue grafts. The first graft served to increase the amount of tissue in the horizontal direction, and the second promoted vertical reconstruction of the defect. RESULTS AND CONCLUSION: In cases with aesthetic requirements, restorative intervention may be able to mask tissue loss, but it can hardly achieve optimal aesthetic results. Periodontal plastic surgery techniques can be used to achieve that ideal result. The clinician must diagnose conditions in order to select correct treatment regimen for each individual case. Key words:Papilla, gingival smile, pontic, restorative dentistry. |
R., Montoya-Salazar Dalmau Torres-Lagares Gómez-Meda V S D Three steps to maintain predictable interdental papilla and gingiva emergence profiles in immediate implant placement. A 3-year follow-up case report Artículo de revista J Clin Exp Dent., 10 (5), pp. e513-e519, 2018. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{Gómez-Meda2018b, title = {Three steps to maintain predictable interdental papilla and gingiva emergence profiles in immediate implant placement. A 3-year follow-up case report}, author = {Montoya-Salazar Dalmau Torres-Lagares V S D Gómez-Meda R.}, url = {https://www.ncbi.nlm.nih.gov/pmc?term=29849979[PMID]&report=imagesdocsum}, doi = {10.4317/jced.54863}, year = {2018}, date = {2018-05-01}, journal = {J Clin Exp Dent.}, volume = {10}, number = {5}, pages = {e513-e519}, abstract = {We present a case that describes a three-step clinical technique to provide guidelines to replace fractured teeth with immediate implant placement using the same dental structure as a temporary crown and a regenerative approach. This approach predictably maintains the interdental papilla and gingiva emergence profile to ensure a favorable cosmetic result. A 3-year follow-up has shown good clinical outcomes and stability in crestal bone levels. Consequently, this is an innovative way to do temporary crown and design restorations in everyday clinical practice. Key words:Interdental papilla, dental implant, inmmediate implant, gingival aesthetics, dental aesthetics.}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } We present a case that describes a three-step clinical technique to provide guidelines to replace fractured teeth with immediate implant placement using the same dental structure as a temporary crown and a regenerative approach. This approach predictably maintains the interdental papilla and gingiva emergence profile to ensure a favorable cosmetic result. A 3-year follow-up has shown good clinical outcomes and stability in crestal bone levels. Consequently, this is an innovative way to do temporary crown and design restorations in everyday clinical practice. Key words:Interdental papilla, dental implant, inmmediate implant, gingival aesthetics, dental aesthetics. |
G., Díaz-Sánchez Torres-Lagares Hernández-Pacheco González-Martín Serrera-Figallo Ruiz-de-León-Hernández R M D E M M A Botulinum toxin A for patients with orofacial dystonia: prospective, observational, single-centre study Artículo de revista Int J Oral Maxillofac Surg., 47 (3), pp. 386-391, 2018. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{Ruiz-de-León-Hernández2018, title = {Botulinum toxin A for patients with orofacial dystonia: prospective, observational, single-centre study}, author = {Díaz-Sánchez Torres-Lagares Hernández-Pacheco González-Martín Serrera-Figallo R M D E M M A Ruiz-de-León-Hernández G.}, doi = {10.1016/j.ijom.2017.11.006}, year = {2018}, date = {2018-03-01}, journal = {Int J Oral Maxillofac Surg.}, volume = {47}, number = {3}, pages = {386-391}, abstract = {The objective of this study was to demonstrate the efficacy of intramuscular botulinum toxin type A (BTX-A) as a method of controlling the symptoms of focal facial dystonia. A prospective, longitudinal, observational, pre-post (case-series) single-centre study was conducted over a period of 3 months, involving 30 patients with focal dystonia. The patients were enrolled on a first-come, first-served basis. For all patients, the abnormal movements were evaluated using the Abnormal Involuntary Movement Scale (AIMS). The AIMS results were recorded immediately before BTX-A injection (primary predictor variable) and after 3 months (the toxin reaches its maximum effect 2 weeks after injection, and the effect is maintained for 3 months). An improvement in AIMS score was the primary outcome variable. Treatment efficacy was evaluated using the Pearson correlation index with a level of significance of P<0.05. The average age of the study subjects was 70.9±12.7years (20 female, 10 male). The mean dose of BTX-A used was 27.4±20.5U. The mean improvement in AIMS score after treatment was 5.2±4.2. A significant correlation was found between the dose applied and the reduction in AIMS score (P<0.05). BTX-A can be used in the treatment of focal dystonia and provides reproducible results.}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } The objective of this study was to demonstrate the efficacy of intramuscular botulinum toxin type A (BTX-A) as a method of controlling the symptoms of focal facial dystonia. A prospective, longitudinal, observational, pre-post (case-series) single-centre study was conducted over a period of 3 months, involving 30 patients with focal dystonia. The patients were enrolled on a first-come, first-served basis. For all patients, the abnormal movements were evaluated using the Abnormal Involuntary Movement Scale (AIMS). The AIMS results were recorded immediately before BTX-A injection (primary predictor variable) and after 3 months (the toxin reaches its maximum effect 2 weeks after injection, and the effect is maintained for 3 months). An improvement in AIMS score was the primary outcome variable. Treatment efficacy was evaluated using the Pearson correlation index with a level of significance of P<0.05. The average age of the study subjects was 70.9±12.7years (20 female, 10 male). The mean dose of BTX-A used was 27.4±20.5U. The mean improvement in AIMS score after treatment was 5.2±4.2. A significant correlation was found between the dose applied and the reduction in AIMS score (P<0.05). BTX-A can be used in the treatment of focal dystonia and provides reproducible results. |
J., Fernández-Olavarría Oliveros-López Torres-Lagares Serrera-Figallo Gutiérrez-Corrales Gutiérrez-Pérez Nuñez-Aguilar A L G D M A A J L Evolution of oral health in oral cancer patients with and without dental treatment in place: Before, during and after cancer treatment Artículo de revista J Clin Exp Dent., 10 (2), pp. e158-e165, 2018. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{Nuñez-Aguilar2018b, title = {Evolution of oral health in oral cancer patients with and without dental treatment in place: Before, during and after cancer treatment}, author = {Fernández-Olavarría Oliveros-López Torres-Lagares Serrera-Figallo Gutiérrez-Corrales Gutiérrez-Pérez A L G D M A A J L Nuñez-Aguilar J.}, url = {https://www.ncbi.nlm.nih.gov/pmc?term=29670734[PMID]&report=imagesdocsum}, doi = {10.4317/jced.54608}, year = {2018}, date = {2018-02-01}, journal = {J Clin Exp Dent.}, volume = {10}, number = {2}, pages = {e158-e165}, abstract = {BACKGROUND: This study aims to evaluate the influence of two dental treatment protocols, outpatient non-regulated treatment versus supervised hospital treatment, on the oral health of patients undergoing oral cancer (only radiochemotherapy treatment, not surgical) treatment. MATERIAL AND METHODS: The study used a quasi-experimental approach justified on ethical grounds. A total of 41 patients were included in the control group (outpatient non-regulated treatment) and 40 patients in the experimental group (in-hospital supervised treatment). The patients were treated only with chemotherapy (not surgical treatment was made) for oral cancer. This decision was taken by the oncology committee of the hospital without being influenced by this study. Data regarding plaque index, daily brushing habits, appearance of new cavities, need for extractions, appearance of candidiasis and use of prosthetics in both groups were collected at three points throughout the study: before starting cancer treatment, during treatment and after treatment. The values obtained using the Student's t-test and chi-squared were compared. RESULTS: Based on similar patient backgrounds, throughout cancer treatment the intervention under study resulted in a decrease in plaque index, necessary extractions, and incidence of decay, as well as an increase in daily brushing among other improvements in oral health observed in the experimental group versus the control group. CONCLUSIONS: From our data, we can confirm that supervised dental treatment performed during oral cancer treatment produced an improvement in the oral health of patients with oral cancer. Key words:Oral cancer, dental treatment, quality of life, oncology, dentistry.}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } BACKGROUND: This study aims to evaluate the influence of two dental treatment protocols, outpatient non-regulated treatment versus supervised hospital treatment, on the oral health of patients undergoing oral cancer (only radiochemotherapy treatment, not surgical) treatment. MATERIAL AND METHODS: The study used a quasi-experimental approach justified on ethical grounds. A total of 41 patients were included in the control group (outpatient non-regulated treatment) and 40 patients in the experimental group (in-hospital supervised treatment). The patients were treated only with chemotherapy (not surgical treatment was made) for oral cancer. This decision was taken by the oncology committee of the hospital without being influenced by this study. Data regarding plaque index, daily brushing habits, appearance of new cavities, need for extractions, appearance of candidiasis and use of prosthetics in both groups were collected at three points throughout the study: before starting cancer treatment, during treatment and after treatment. The values obtained using the Student's t-test and chi-squared were compared. RESULTS: Based on similar patient backgrounds, throughout cancer treatment the intervention under study resulted in a decrease in plaque index, necessary extractions, and incidence of decay, as well as an increase in daily brushing among other improvements in oral health observed in the experimental group versus the control group. CONCLUSIONS: From our data, we can confirm that supervised dental treatment performed during oral cancer treatment produced an improvement in the oral health of patients with oral cancer. Key words:Oral cancer, dental treatment, quality of life, oncology, dentistry. |
2017 |
R.M., Castillo-Dalí Fernández-Olavarría Mosquera-Pérez Delgado-Muñoz Gutiérrez-Pérez Torres-Lagares Díaz Sánchez G A R J M J L D A Prospective, Double-Blind, Randomized, Controlled Clinical Trial in the Gingivitis Prevention with an Oligomeric Proanthocyanidin Nutritional Supplement Artículo de revista Mediators Inflamm, 7460780 (.), pp. ., 2017. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{Sánchez2017, title = {A Prospective, Double-Blind, Randomized, Controlled Clinical Trial in the Gingivitis Prevention with an Oligomeric Proanthocyanidin Nutritional Supplement}, author = {Castillo-Dalí Fernández-Olavarría Mosquera-Pérez Delgado-Muñoz Gutiérrez-Pérez Torres-Lagares G A R J M J L D Díaz Sánchez R.M.}, doi = {10.1155/2017/7460780}, year = {2017}, date = {2017-12-10}, journal = {Mediators Inflamm}, volume = {7460780}, number = {.}, pages = {.}, abstract = {AIM: To evaluate the effectiveness on tissue response of the new nutritional supplement made of oligomeric proanthocyanidins in induced gingivitis after 21 days of use. MATERIAL AND METHODS: A prospective, double-blind, randomized, controlled clinical trial was carried out on 20 patients; it is divided into an experimental group and a control group after fulfilling the selection criteria. Patients had to come 4 times during the study to register the Silness and Löe index, the gingival bleeding index, the plaque index, the inflammatory crevicular fluid study (IL6), and the changes in the brightness of the gingiva. No complementary hygiene methods were allowed during the 21 days. RESULTS: The Silness and Löe index was higher in the control group than in the experimental group, reaching a twofold difference between the groups (p < 0.0001). The gingival bleeding index also supports this fact, since the bleeding was lower in the experimental group (p < 0.005). However, the dental plaque on the tooth surface according to the plaque index was 33% higher in the experimental group (p < 0.006). Some differences in the IL-6 were found in the crevicular fluid (p < 0.0001). CONCLUSION: Oligomeric proanthocyanidins have an effect on the periodontal tissue's health. No effects on the accumulation of plaque on the tooth surface were found, so further studies are needed to determine the nature of the plaque.}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } AIM: To evaluate the effectiveness on tissue response of the new nutritional supplement made of oligomeric proanthocyanidins in induced gingivitis after 21 days of use. MATERIAL AND METHODS: A prospective, double-blind, randomized, controlled clinical trial was carried out on 20 patients; it is divided into an experimental group and a control group after fulfilling the selection criteria. Patients had to come 4 times during the study to register the Silness and Löe index, the gingival bleeding index, the plaque index, the inflammatory crevicular fluid study (IL6), and the changes in the brightness of the gingiva. No complementary hygiene methods were allowed during the 21 days. RESULTS: The Silness and Löe index was higher in the control group than in the experimental group, reaching a twofold difference between the groups (p < 0.0001). The gingival bleeding index also supports this fact, since the bleeding was lower in the experimental group (p < 0.005). However, the dental plaque on the tooth surface according to the plaque index was 33% higher in the experimental group (p < 0.006). Some differences in the IL-6 were found in the crevicular fluid (p < 0.0001). CONCLUSION: Oligomeric proanthocyanidins have an effect on the periodontal tissue's health. No effects on the accumulation of plaque on the tooth surface were found, so further studies are needed to determine the nature of the plaque. |
G., Díaz-Sánchez Torres-Lagares Hernández-Pacheco González-Martín Serrera-Figallo Ruiz-de-León-Hernández R M D E M M A Botulinum toxin A for patients with orofacial dystonia: prospective, observational, single-centre study Artículo de revista Int J Oral Maxillofac Surg., 47 (3), pp. 386-391, 2017. Resumen | Enlaces | BibTeX | Etiquetas: @article{Ruiz-de-León-Hernández2017, title = {Botulinum toxin A for patients with orofacial dystonia: prospective, observational, single-centre study}, author = {Díaz-Sánchez Torres-Lagares Hernández-Pacheco González-Martín Serrera-Figallo R M D E M M A Ruiz-de-León-Hernández G.}, doi = {10.1016/j.ijom.2017.11.006}, year = {2017}, date = {2017-12-06}, journal = {Int J Oral Maxillofac Surg.}, volume = {47}, number = {3}, pages = {386-391}, abstract = {The objective of this study was to demonstrate the efficacy of intramuscular botulinum toxin type A (BTX-A) as a method of controlling the symptoms of focal facial dystonia. A prospective, longitudinal, observational, pre-post (case-series) single-centre study was conducted over a period of 3 months, involving 30 patients with focal dystonia. The patients were enrolled on a first-come, first-served basis. For all patients, the abnormal movements were evaluated using the Abnormal Involuntary Movement Scale (AIMS). The AIMS results were recorded immediately before BTX-A injection (primary predictor variable) and after 3 months (the toxin reaches its maximum effect 2 weeks after injection, and the effect is maintained for 3 months). An improvement in AIMS score was the primary outcome variable. Treatment efficacy was evaluated using the Pearson correlation index with a level of significance of P<0.05. The average age of the study subjects was 70.9±12.7years (20 female, 10 male). The mean dose of BTX-A used was 27.4±20.5U. The mean improvement in AIMS score after treatment was 5.2±4.2. A significant correlation was found between the dose applied and the reduction in AIMS score (P<0.05). BTX-A can be used in the treatment of focal dystonia and provides reproducible results.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The objective of this study was to demonstrate the efficacy of intramuscular botulinum toxin type A (BTX-A) as a method of controlling the symptoms of focal facial dystonia. A prospective, longitudinal, observational, pre-post (case-series) single-centre study was conducted over a period of 3 months, involving 30 patients with focal dystonia. The patients were enrolled on a first-come, first-served basis. For all patients, the abnormal movements were evaluated using the Abnormal Involuntary Movement Scale (AIMS). The AIMS results were recorded immediately before BTX-A injection (primary predictor variable) and after 3 months (the toxin reaches its maximum effect 2 weeks after injection, and the effect is maintained for 3 months). An improvement in AIMS score was the primary outcome variable. Treatment efficacy was evaluated using the Pearson correlation index with a level of significance of P<0.05. The average age of the study subjects was 70.9±12.7years (20 female, 10 male). The mean dose of BTX-A used was 27.4±20.5U. The mean improvement in AIMS score after treatment was 5.2±4.2. A significant correlation was found between the dose applied and the reduction in AIMS score (P<0.05). BTX-A can be used in the treatment of focal dystonia and provides reproducible results. |
L., Corcuera-Flores Mesa-Cabrera Cabrera-Domínguez Torres-Lagares Machuca-Portillo Castellanos-Cosano J R M J D G Dental implants placement in paranoid squizofrenic patient with obsessive-compulsive disorder: A case report Artículo de revista J Clin Exp Dent., 9 (11), pp. e1371-e1374, 2017. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{Castellanos-Cosano2017, title = {Dental implants placement in paranoid squizofrenic patient with obsessive-compulsive disorder: A case report}, author = {Corcuera-Flores Mesa-Cabrera Cabrera-Domínguez Torres-Lagares Machuca-Portillo J R M J D G Castellanos-Cosano L.}, url = {https://www.ncbi.nlm.nih.gov/pmc/?term=29302292%5BPMID%5D&report=imagesdocsum}, doi = {10.4317/jced.54356}, year = {2017}, date = {2017-11-01}, journal = {J Clin Exp Dent.}, volume = {9}, number = {11}, pages = {e1371-e1374}, abstract = {BACKGROUND: Paranoid schizophrenia is a mental illness that involves no observable anatomical alteration. Main characteristic affects the personality of the individual, as well as areas of his own psychology. CASE REPORT: A 33-year-old man with paranoid schizophrenia and obsessive-compulsive disorder in treatment with Haloperidol, Oxcarbazepine, Olanzapine and Seroquel is presented. Dental exploration showed widespread decay mostly cervical with numerous root fragments, agenesis of lateral incisors, impacted wisdom teeth, missing teeth and malocclusion. Treatment plan included restoration of teeth decay, extractions of root fragments and implant-supported prostheses in bilateral upper lateral incisors for aesthetics reason. A previous consultation with a psychiatric specialist was performed and no contraindication were observed. A preliminary radiological examination was performed previous dental treatment and implant placement. Due to patient refusal to replace dental abscenses with implants, inform consent was signed up from his parents. After local anesthesia, first implant was placed at upper right lateral positions (Straumann Bone Level Ø 3.3 mm, length 10 mm). Two weeks later a second implant was placed at upper left lateral position (Straumann Bone Level Ø 3.3 mm, length 12 mm). The patient showed no postoperative complications. After implant placement, the patient attended scheduled review appointments. The prosthesis was placed after a 3-month period of osseointegration. CONCLUSIONS: Implant placement can be considered a suitable option for people with mental disorders. A previous consultation with psychiatric specialists for conducting a good patient management is necessaire. Key words:Paranoid schizophrenia, obsessive-compulsive disorder, dental implants.}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } BACKGROUND: Paranoid schizophrenia is a mental illness that involves no observable anatomical alteration. Main characteristic affects the personality of the individual, as well as areas of his own psychology. CASE REPORT: A 33-year-old man with paranoid schizophrenia and obsessive-compulsive disorder in treatment with Haloperidol, Oxcarbazepine, Olanzapine and Seroquel is presented. Dental exploration showed widespread decay mostly cervical with numerous root fragments, agenesis of lateral incisors, impacted wisdom teeth, missing teeth and malocclusion. Treatment plan included restoration of teeth decay, extractions of root fragments and implant-supported prostheses in bilateral upper lateral incisors for aesthetics reason. A previous consultation with a psychiatric specialist was performed and no contraindication were observed. A preliminary radiological examination was performed previous dental treatment and implant placement. Due to patient refusal to replace dental abscenses with implants, inform consent was signed up from his parents. After local anesthesia, first implant was placed at upper right lateral positions (Straumann Bone Level Ø 3.3 mm, length 10 mm). Two weeks later a second implant was placed at upper left lateral position (Straumann Bone Level Ø 3.3 mm, length 12 mm). The patient showed no postoperative complications. After implant placement, the patient attended scheduled review appointments. The prosthesis was placed after a 3-month period of osseointegration. CONCLUSIONS: Implant placement can be considered a suitable option for people with mental disorders. A previous consultation with psychiatric specialists for conducting a good patient management is necessaire. Key words:Paranoid schizophrenia, obsessive-compulsive disorder, dental implants. |
J., Castellanos-Cosano Torres-Lagares Machuca-Portillo Cabrera-Domínguez L D G A Prospective Case-Control Clinical Study of Titanium-Zirconium Alloy Implants with a Hydrophilic Surface in Patients with Type 2 Diabetes Mellitus Artículo de revista Int J Oral Maxillofac Implants., 32 (5), pp. 1135-1144, 2017. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{Cabrera-Domínguez2017, title = {A Prospective Case-Control Clinical Study of Titanium-Zirconium Alloy Implants with a Hydrophilic Surface in Patients with Type 2 Diabetes Mellitus}, author = {Castellanos-Cosano Torres-Lagares Machuca-Portillo L D G Cabrera-Domínguez J.}, doi = {10.11607/jomi.5577}, year = {2017}, date = {2017-10-01}, journal = {Int J Oral Maxillofac Implants.}, volume = {32}, number = {5}, pages = {1135-1144}, abstract = {PURPOSE: To evaluate prospectively the behavior of narrow-diameter (3.3-mm) titanium-zirconium alloy implants with a hydrophilic surface (Straumann Roxolid SLActive) in patients with type 2 diabetes mellitus in single-unit restorations, compared with a healthy control group (assessed using the glycosylated hemoglobin HbA1c test). MATERIALS AND METHODS: The patients evaluated in this study required single-unit implant treatment; 15 patients had type 2 diabetes mellitus, and 14 patients were healthy (control group [CG]). Marginal bone level (MBL) change around the implants was evaluated using conventional, sequential periapical digital radiographs. Patient HbA1c was assessed in each check-up. Normality test (Kolmogorov-Smirnov), univariate and multivariate logistic regression, analysis of variance (ANOVA), and Mann-Whitney U test were used for statistical analysis. RESULTS: No differences in MBL change and implant survival and success rates were found between the diabetes mellitus group (DMG) versus the control group, either during the initial recording (DMG, 0.99 ± 0.56 vs CG, 0.68 ± 0.54; P > .05) or 6 months after restoration (DMG, 1.28 ± 0.38 vs CG, 1.11 ± 0.59; P > .05). No significant correlation between HbA1c levels and MBL change was detected in these patients (P > .05). CONCLUSION: Patients with glycemic control exhibit similar outcomes to healthy individuals with regard to the investigated parameters. In light of these findings, the titanium-zirconium alloy small-diameter implants can be used in the anterior region of the mouth in type 2 diabetic patients.}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } PURPOSE: To evaluate prospectively the behavior of narrow-diameter (3.3-mm) titanium-zirconium alloy implants with a hydrophilic surface (Straumann Roxolid SLActive) in patients with type 2 diabetes mellitus in single-unit restorations, compared with a healthy control group (assessed using the glycosylated hemoglobin HbA1c test). MATERIALS AND METHODS: The patients evaluated in this study required single-unit implant treatment; 15 patients had type 2 diabetes mellitus, and 14 patients were healthy (control group [CG]). Marginal bone level (MBL) change around the implants was evaluated using conventional, sequential periapical digital radiographs. Patient HbA1c was assessed in each check-up. Normality test (Kolmogorov-Smirnov), univariate and multivariate logistic regression, analysis of variance (ANOVA), and Mann-Whitney U test were used for statistical analysis. RESULTS: No differences in MBL change and implant survival and success rates were found between the diabetes mellitus group (DMG) versus the control group, either during the initial recording (DMG, 0.99 ± 0.56 vs CG, 0.68 ± 0.54; P > .05) or 6 months after restoration (DMG, 1.28 ± 0.38 vs CG, 1.11 ± 0.59; P > .05). No significant correlation between HbA1c levels and MBL change was detected in these patients (P > .05). CONCLUSION: Patients with glycemic control exhibit similar outcomes to healthy individuals with regard to the investigated parameters. In light of these findings, the titanium-zirconium alloy small-diameter implants can be used in the anterior region of the mouth in type 2 diabetic patients. |
D., Castellanos-Cosano Serrera-Figallo García-García López-Santos Barranco Rodríguez-Gonzalez Felipe Rivera-Jiménez Gutiérrez-Pérez Torres-Lagares L M Á F J C A A C J L Polymers (Basel), 9 (9), pp. E410, 2017. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{Torres-Lagares2017, title = {In Vitro and in Vivo Study of Poly(Lactic⁻co⁻Glycolic) (PLGA) Membranes Treated with Oxygen Plasma and Coated with Nanostructured Hydroxyapatite Ultrathin Films for Guided Bone Regeneration Processes}, author = {Castellanos-Cosano Serrera-Figallo García-García López-Santos Barranco Rodríguez-Gonzalez Felipe Rivera-Jiménez Gutiérrez-Pérez L M Á F J C A A C J L Torres-Lagares D.}, url = {https://www.ncbi.nlm.nih.gov/pmc/?term=30965714%5BPMID%5D&report=imagesdocsum}, doi = {10.3390/polym9090410}, year = {2017}, date = {2017-09-02}, journal = {Polymers (Basel)}, volume = {9}, number = {9}, pages = {E410}, abstract = {The novelty of this study is the addition of an ultrathin layer of nanostructured hydroxyapatite (HA) on oxygen plasma modified poly(lactic⁻co⁻glycolic) (PLGA) membranes (PO₂) in order to evaluate the efficiency of this novel material in bone regeneration. METHODS: Two groups of regenerative membranes were prepared: PLGA (control) and PLGA/PO₂/HA (experimental). These membranes were subjected to cell cultures and then used to cover bone defects prepared on the skulls of eight experimental rabbits. RESULTS: Cell morphology and adhesion of the osteoblasts to the membranes showed that the osteoblasts bound to PLGA were smaller and with a lower number of adhered cells than the osteoblasts bound to the PLGA/PO₂/HA membrane (p < 0.05). The PLGA/PO₂/HA membrane had a higher percentage of viable cells bound than the control membrane (p < 0.05). Both micro-CT and histological evaluation confirmed that PLGA/PO₂/HA membranes enhance bone regeneration. A statistically significant difference in the percentage of osteoid area in relation to the total area between both groups was found. CONCLUSIONS: The incorporation of nanometric layers of nanostructured HA into PLGA membranes modified with PO₂ might be considered for the regeneration of bone defects. PLGA/PO₂/HA membranes promote higher osteosynthetic activity, new bone formation, and mineralisation than the PLGA control group.}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } The novelty of this study is the addition of an ultrathin layer of nanostructured hydroxyapatite (HA) on oxygen plasma modified poly(lactic⁻co⁻glycolic) (PLGA) membranes (PO₂) in order to evaluate the efficiency of this novel material in bone regeneration. METHODS: Two groups of regenerative membranes were prepared: PLGA (control) and PLGA/PO₂/HA (experimental). These membranes were subjected to cell cultures and then used to cover bone defects prepared on the skulls of eight experimental rabbits. RESULTS: Cell morphology and adhesion of the osteoblasts to the membranes showed that the osteoblasts bound to PLGA were smaller and with a lower number of adhered cells than the osteoblasts bound to the PLGA/PO₂/HA membrane (p < 0.05). The PLGA/PO₂/HA membrane had a higher percentage of viable cells bound than the control membrane (p < 0.05). Both micro-CT and histological evaluation confirmed that PLGA/PO₂/HA membranes enhance bone regeneration. A statistically significant difference in the percentage of osteoid area in relation to the total area between both groups was found. CONCLUSIONS: The incorporation of nanometric layers of nanostructured HA into PLGA membranes modified with PO₂ might be considered for the regeneration of bone defects. PLGA/PO₂/HA membranes promote higher osteosynthetic activity, new bone formation, and mineralisation than the PLGA control group. |
R., Castillo-Dalí Corcuera-Flores Serrera-Figallo Castillo-Oyagüe González-Martín Gutierrez-Pérez Torres-Lagares Velázquez-Cayón G J R M A R M J L D Production of bone mineral material and BMP-2 in osteoblasts cultured on double acid-etched titanium Artículo de revista Med Oral Patol Oral Cir Bucal, 22 (5), pp. e651-e659, 2017. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{Velázquez-Cayón2017, title = {Production of bone mineral material and BMP-2 in osteoblasts cultured on double acid-etched titanium}, author = {Castillo-Dalí Corcuera-Flores Serrera-Figallo Castillo-Oyagüe González-Martín Gutierrez-Pérez Torres-Lagares G J R M A R M J L D Velázquez-Cayón R.}, url = {https://www.ncbi.nlm.nih.gov/pmc/?term=28809380%5BPMID%5D&report=imagesdocsum}, doi = {10.4317/medoral.22071}, year = {2017}, date = {2017-09-01}, journal = {Med Oral Patol Oral Cir Bucal}, volume = {22}, number = {5}, pages = {e651-e659}, abstract = {BACKGROUND: The study of osteoblasts and their osteogenic functions is essential in order to understand them and their applications in implantology. In this sense, this study try to study BMP-2 production and bone matrix deposition, in addition to other biological variables, in osteoblasts cultured on a rough double acid-etched titanium surface (Osseotite®, Biomet 3i, Palm Beach Garden, Florida, USA) in comparison to a smooth titanium surface (machined) and a control Petri dish. MATERIALS AND METHODS: An in vitro prospective study. NHOst human osteoblasts from the femur were cultured on three different surfaces: Control group: 25-mm methacrylate dish (n = 6); Machined group: titanium discs with machined surface (n = 6) and Experimental group: titanium discs with a double acid-etched nitric and hydrofluoric Osseotite® acid surface (n = 6). A quantification of the mitochondrial membrane potential, and studies of apoptosis, mobility and adhesion, bone productivity (BMP-2) and cellular bone synthesis were carried out after culturing the three groups for forty-eight hours. RESULTS: A statistically significant difference was observed in the production of BMP-2 between the experimental group and the other two groups (22.33% ± 11.06 vs. 13.10% ± 5.51 in the machined group and 3.88% ± 3.43 in the control group). Differences in cellular bone synthesis were also observed between the groups (28.34% ± 14.4% in the experimental group vs. 20.03% ± 6.79 in the machined group and 19.34% ± 15.93% in the control group). CONCLUSIONS: In comparison with machined surfaces, Osseotite® surfaces favor BMP-2 production and bone synthesis as a result of the osteoblasts in contact with it.}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } BACKGROUND: The study of osteoblasts and their osteogenic functions is essential in order to understand them and their applications in implantology. In this sense, this study try to study BMP-2 production and bone matrix deposition, in addition to other biological variables, in osteoblasts cultured on a rough double acid-etched titanium surface (Osseotite®, Biomet 3i, Palm Beach Garden, Florida, USA) in comparison to a smooth titanium surface (machined) and a control Petri dish. MATERIALS AND METHODS: An in vitro prospective study. NHOst human osteoblasts from the femur were cultured on three different surfaces: Control group: 25-mm methacrylate dish (n = 6); Machined group: titanium discs with machined surface (n = 6) and Experimental group: titanium discs with a double acid-etched nitric and hydrofluoric Osseotite® acid surface (n = 6). A quantification of the mitochondrial membrane potential, and studies of apoptosis, mobility and adhesion, bone productivity (BMP-2) and cellular bone synthesis were carried out after culturing the three groups for forty-eight hours. RESULTS: A statistically significant difference was observed in the production of BMP-2 between the experimental group and the other two groups (22.33% ± 11.06 vs. 13.10% ± 5.51 in the machined group and 3.88% ± 3.43 in the control group). Differences in cellular bone synthesis were also observed between the groups (28.34% ± 14.4% in the experimental group vs. 20.03% ± 6.79 in the machined group and 19.34% ± 15.93% in the control group). CONCLUSIONS: In comparison with machined surfaces, Osseotite® surfaces favor BMP-2 production and bone synthesis as a result of the osteoblasts in contact with it. |
L., Fernandez-Olavarria Torres-Lagares Serrera-Figallo Castillo-Oyagüe Segura-Egea Gutierrez-Perez Oliveros-Lopez A D M A R J J J L Reduction rate by decompression as a treatment of odontogenic cysts Artículo de revista Med Oral Patol Oral Cir Bucal, 22 (5), pp. e643-e650, 2017. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{Oliveros-Lopez2017, title = {Reduction rate by decompression as a treatment of odontogenic cysts}, author = {Fernandez-Olavarria Torres-Lagares Serrera-Figallo Castillo-Oyagüe Segura-Egea Gutierrez-Perez A D M A R J J J L Oliveros-Lopez L.}, url = {https://www.ncbi.nlm.nih.gov/pmc?term=28809378[PMID]&report=imagesdocsum}, doi = {10.4317/medoral.21916}, year = {2017}, date = {2017-09-01}, journal = {Med Oral Patol Oral Cir Bucal}, volume = {22}, number = {5}, pages = {e643-e650}, abstract = {BACKGROUND: Odontogenic cysts are defined as those cysts that arise from odontogenic epithelium and occur in the tooth-bearing regions of the jaws. Cystectomy, marsupialization or decompression of odontogenic cyst are treatment approach to this pathology. The aim of this study was to evaluate the effectiveness of the decompression as the primary treatment of the cystic lesions of the jaws and them reduction rates involving different factors. MATERIAL AND METHODS: 23 patients with odontogenic cysts of the jaws, previously diagnosed by anatomical histopathology (follicular cysts (7) and radicular cysts (16)) underwent decompression as an initial treatment. Clinical examination and pre and post panoramic radiograph were measured and analyzed. In addition, data as gender, age, time reduction and location of the lesion were collected. RESULTS: Significant results were obtained in relation to the location of lesions and the reduction rate (p<0.01). In a higher initial lesion, a greater reduction rate was observed (p<0.05). CONCLUSIONS: Decompression as an initial treatment of cystic lesions of the jaws was effective; it reduces the size of the lesions avoiding a possible damage to adjacent structures. Cystic lesions in the mandible, regardless of the area where they occur will have a higher reduction rate if it is compared with the maxilla. Similar behavior was identified in large lesions compared to smaller.}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } BACKGROUND: Odontogenic cysts are defined as those cysts that arise from odontogenic epithelium and occur in the tooth-bearing regions of the jaws. Cystectomy, marsupialization or decompression of odontogenic cyst are treatment approach to this pathology. The aim of this study was to evaluate the effectiveness of the decompression as the primary treatment of the cystic lesions of the jaws and them reduction rates involving different factors. MATERIAL AND METHODS: 23 patients with odontogenic cysts of the jaws, previously diagnosed by anatomical histopathology (follicular cysts (7) and radicular cysts (16)) underwent decompression as an initial treatment. Clinical examination and pre and post panoramic radiograph were measured and analyzed. In addition, data as gender, age, time reduction and location of the lesion were collected. RESULTS: Significant results were obtained in relation to the location of lesions and the reduction rate (p<0.01). In a higher initial lesion, a greater reduction rate was observed (p<0.05). CONCLUSIONS: Decompression as an initial treatment of cystic lesions of the jaws was effective; it reduces the size of the lesions avoiding a possible damage to adjacent structures. Cystic lesions in the mandible, regardless of the area where they occur will have a higher reduction rate if it is compared with the maxilla. Similar behavior was identified in large lesions compared to smaller. |
R., Castellanos-Cosano Serrera-Figallo Gutiérrez-Corrales Gonzalez-Martin Gutiérrez-Pérez Flores-Ruiz L M A A M J L Evolution of oral cancer treatment in an andalusian population sample: Rehabilitation with prosthetic obturation and removable partial prosthesis Artículo de revista J Clin Exp Dent., 9 (8), pp. e1008-e1014, 2017. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{Flores-Ruiz2017, title = {Evolution of oral cancer treatment in an andalusian population sample: Rehabilitation with prosthetic obturation and removable partial prosthesis}, author = {Castellanos-Cosano Serrera-Figallo Gutiérrez-Corrales Gonzalez-Martin Gutiérrez-Pérez L M A A M J L Flores-Ruiz R.}, doi = {10.4317/jced.54023}, year = {2017}, date = {2017-08-01}, journal = {J Clin Exp Dent.}, volume = {9}, number = {8}, pages = {e1008-e1014}, abstract = {BACKGROUND: Radical surgical resection as a treatment modality for oral cancer often leads to an extensive deficit in both the maxillary and mandibular levels, where the use of a palatal obturator prosthesis (POP) or removable partial denture (RPP). The aim of this study was to evaluate the treatment with POP and RPP in patients treated for oral cancer in the Unit of Prosthetic Rehabilitation of the University Hospital Virgen del Rocío in a period of 20 years. MATERIAL AND METHODS: Retrospective descriptive study during the years 1991 and 2011 analyzing oral cancer type, characteristics, treatment and follow-up. The sample consisted of patients whose tumor had previously been removed and who had been referred to the Oncological Rehabilitation Unit of the Oral and Maxillofacial Surgery Unit of the "Virgen del Rocío" University Hospital for rehabilitation. The inclusion criteria were patients whose underlying pathology was any type of neoplasia, which after its treatment had been referred to the aforementioned Oncological Prosthetic Rehabilitation unit. RESULTS: Of the 45 patients included in our study, 15 patients were rehabilitated with palatal obturator (33.3%) and 5 patients with removable partial denture (11.1%). The mean age of the sample of patients with POP was 57.3 ± 9.23, while the mean age of the sample of patients with RPP was 58 ± 13.5. The most common underlying pathology in patients with POP was squamous cell carcinoma (60%), whereas in patients with RPP it was 100%. The most frequent location found among POP patients was the upper jaw, while in the PRP patients there was no predominant location. The univariate and multivariate logistic regressions did not show any statistically significant association between the independent variables age, sex, smoking habit and alcoholic habit with the dependent variable type of rehabilitating prosthesis. CONCLUSIONS: Based on our data, we can conclude that RPP is used in few cases of oncological rehabilitation. The POP has a greater use, as long as the defect in the bones of the facial middle third is limited. Key words:Head and neck cancer, reconstructive surgery, Palatal obturators, removable partial dentures.}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } BACKGROUND: Radical surgical resection as a treatment modality for oral cancer often leads to an extensive deficit in both the maxillary and mandibular levels, where the use of a palatal obturator prosthesis (POP) or removable partial denture (RPP). The aim of this study was to evaluate the treatment with POP and RPP in patients treated for oral cancer in the Unit of Prosthetic Rehabilitation of the University Hospital Virgen del Rocío in a period of 20 years. MATERIAL AND METHODS: Retrospective descriptive study during the years 1991 and 2011 analyzing oral cancer type, characteristics, treatment and follow-up. The sample consisted of patients whose tumor had previously been removed and who had been referred to the Oncological Rehabilitation Unit of the Oral and Maxillofacial Surgery Unit of the "Virgen del Rocío" University Hospital for rehabilitation. The inclusion criteria were patients whose underlying pathology was any type of neoplasia, which after its treatment had been referred to the aforementioned Oncological Prosthetic Rehabilitation unit. RESULTS: Of the 45 patients included in our study, 15 patients were rehabilitated with palatal obturator (33.3%) and 5 patients with removable partial denture (11.1%). The mean age of the sample of patients with POP was 57.3 ± 9.23, while the mean age of the sample of patients with RPP was 58 ± 13.5. The most common underlying pathology in patients with POP was squamous cell carcinoma (60%), whereas in patients with RPP it was 100%. The most frequent location found among POP patients was the upper jaw, while in the PRP patients there was no predominant location. The univariate and multivariate logistic regressions did not show any statistically significant association between the independent variables age, sex, smoking habit and alcoholic habit with the dependent variable type of rehabilitating prosthesis. CONCLUSIONS: Based on our data, we can conclude that RPP is used in few cases of oncological rehabilitation. The POP has a greater use, as long as the defect in the bones of the facial middle third is limited. Key words:Head and neck cancer, reconstructive surgery, Palatal obturators, removable partial dentures. |
J.C., Castillo-Oyagüe Serrera-Figallo Garrido-Serrano Lynch Menéndez-Collar Torres-Lagares Gutiérrez-Pérez Casar-Espinosa R M Á R C D M D J L Combination of straight and tilted implants for supporting screw-retained dental prostheses in atrophic posterior maxillae: A 2-year prospective study Artículo de revista J Dent., 63 , pp. 85-93, 2017. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{Casar-Espinosa2017, title = {Combination of straight and tilted implants for supporting screw-retained dental prostheses in atrophic posterior maxillae: A 2-year prospective study}, author = {Castillo-Oyagüe Serrera-Figallo Garrido-Serrano Lynch Menéndez-Collar Torres-Lagares Gutiérrez-Pérez R M Á R C D M D J L Casar-Espinosa J.C.}, doi = {10.1016/j.jdent.2017.05.022}, year = {2017}, date = {2017-08-01}, journal = {J Dent.}, volume = {63}, pages = {85-93}, abstract = {OBJECTIVES: To evaluate the two-year survival rate (SR) and marginal bone loss (MBL) of fixed dental prostheses (FDPs) supported by straight (S) and tilted (T) implants under the influence of diverse study variables. METHODS: A prospective investigation comprising 21 patients provided with a total of 27 maxillary screw-retained restorations fixed to 70 dental implants was developed. Two groups of implants were considered depending on their inclination with respect to the occlusal plane: Group 1 (S}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } OBJECTIVES: To evaluate the two-year survival rate (SR) and marginal bone loss (MBL) of fixed dental prostheses (FDPs) supported by straight (S) and tilted (T) implants under the influence of diverse study variables. METHODS: A prospective investigation comprising 21 patients provided with a total of 27 maxillary screw-retained restorations fixed to 70 dental implants was developed. Two groups of implants were considered depending on their inclination with respect to the occlusal plane: Group 1 (S |
M., Machuca-Portillo Torres-Lagares Lesclous Amérigo-Navarro González-Cámpora Amérigo-Góngora G D P J R Clinicopathological and immunohistochemical analysis of oral melanocytic nevi and review of the literature. Artículo de revista J Stomatol Oral Maxillofac Surg., 118 (3), pp. 151-155, 2017. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{Amérigo-Góngora2017, title = {Clinicopathological and immunohistochemical analysis of oral melanocytic nevi and review of the literature.}, author = {Machuca-Portillo Torres-Lagares Lesclous Amérigo-Navarro González-Cámpora G D P J R Amérigo-Góngora M.}, doi = {10.1016/j.jormas.2017.03.003}, year = {2017}, date = {2017-06-01}, journal = {J Stomatol Oral Maxillofac Surg.}, volume = {118}, number = {3}, pages = {151-155}, abstract = {INTRODUCTION: Oral melanocytic nevi (OMNs) are uncommon benign melanocytic tumors, histologically similar to their cutaneous counterparts. The aim of this study was twofold: to contribute to the epidemiology with a literature review with the first Spanish series of OMNs, and to report on clinicopathological, immunohistochemical and demographic findings. MATERIALS AND METHODS: A retrospective analysis of cases attended over the period 1999-2010 was carried out using data drawn from the pathology unit files at two public hospitals in the Spanish region of Andalusia, serving between them a population of 823.614 inhabitants (11%). RESULTS: Ten cases of OMNs were retrieved, accounting for 0.18% of the total 5499 oral biopsies performed over the period. The female-to-male ratio was 1.5:1; mean patient age was 30. The palate was the most common location (70%). Relative frequencies of histologic types were as follows: subepithelial (40%), common blue (30%), compound (20%) and junctional (10%). Immunohistochemical examination showed strong S-100 protein expression, variable reactivity to HMB-45 and high c-Kit expression by junctional melanocytes. Ki-67 was ≤3 in all cases. CONCLUSIONS: Although this first clinicopathologic analysis of OMNs reported in Spain was based on a small patient series, the results are in line with those reported in larger series and additionally provide new demographic data. Since OMNs and early melanomas are usually detected at routine dental examination, detailed oral exploration should always be performed, and in case of doubt a biopsy should be taken to ensure an accurate diagnosis.}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } INTRODUCTION: Oral melanocytic nevi (OMNs) are uncommon benign melanocytic tumors, histologically similar to their cutaneous counterparts. The aim of this study was twofold: to contribute to the epidemiology with a literature review with the first Spanish series of OMNs, and to report on clinicopathological, immunohistochemical and demographic findings. MATERIALS AND METHODS: A retrospective analysis of cases attended over the period 1999-2010 was carried out using data drawn from the pathology unit files at two public hospitals in the Spanish region of Andalusia, serving between them a population of 823.614 inhabitants (11%). RESULTS: Ten cases of OMNs were retrieved, accounting for 0.18% of the total 5499 oral biopsies performed over the period. The female-to-male ratio was 1.5:1; mean patient age was 30. The palate was the most common location (70%). Relative frequencies of histologic types were as follows: subepithelial (40%), common blue (30%), compound (20%) and junctional (10%). Immunohistochemical examination showed strong S-100 protein expression, variable reactivity to HMB-45 and high c-Kit expression by junctional melanocytes. Ki-67 was ≤3 in all cases. CONCLUSIONS: Although this first clinicopathologic analysis of OMNs reported in Spain was based on a small patient series, the results are in line with those reported in larger series and additionally provide new demographic data. Since OMNs and early melanomas are usually detected at routine dental examination, detailed oral exploration should always be performed, and in case of doubt a biopsy should be taken to ensure an accurate diagnosis. |
F., Garrido-Serrano Castillo-Dalí Serrera-Figallo Gañán-Calvo Torres-Lagares Azcarate-Velázquez R G M A A D Effectiveness of flossing loops in the control of the gingival health Artículo de revista J Clin Exp Dent, 9 (6), pp. e756-e761, 2017. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{Azcarate-Velázquez2017, title = {Effectiveness of flossing loops in the control of the gingival health}, author = {Garrido-Serrano Castillo-Dalí Serrera-Figallo Gañán-Calvo Torres-Lagares R G M A A D Azcarate-Velázquez F.}, url = {https://www.ncbi.nlm.nih.gov/pmc?term=28638551[PMID]&report=imagesdocsum}, doi = {10.4317/jced.53858}, year = {2017}, date = {2017-06-01}, journal = {J Clin Exp Dent}, volume = {9}, number = {6}, pages = {e756-e761}, abstract = {BACKGROUND: One of the key factor in the good condition of periodontal tissues is their daily hygiene. Oral hygiene techniques such brushing and a good interdental hygiene by correct flossing are very important. The aim of this study is to compare the use of dental floss in a loop vs traditional floss in the control of Loe-Silness Gingival Index (IG), Turesky´s Plaque Index (IPT), Gingival Bleeding Index (IS) and the values of interleukin 6 (IL-6) and interleukin 8 (IL-8). MATERIAL AND METHODS: A comparative study of 40 patients in which each patient was his own control, using during 45 days each one of the devices (new loop floss and conventional floss) of interdental hygiene analysed. Data for Loe-Silness Gingival Index (IG), Turesky´s Plaque Index (IPT), Gingival Bleeding Index (IS) and the values of interleukin 6 (IL-6) and interleukin 8 (IL-8)were collected and measured in every visit for every type of interdental hygiene device. RESULTS: Our data indicates that the rate of Turesky´s Plaque Index presented statistically significant differences between groups (loop: 1.66 ± 0.8; traditional: 1.12 ± 0.8; p<0.0001). The rest of the indices studied showed no statistically significant differences. CONCLUSIONS: The creation of new dental floss designs try to make their use easier and more sensitive, and plaque removal more effective. The loop design can facilitate interdental hygiene, reaching similar effectiveness than traditional floss, improving some indicators, such as Turesky´s Plaque Index. Key words:Dental floss, bacterial plaque, loop floss, plaque index, periodontal diseases.}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } BACKGROUND: One of the key factor in the good condition of periodontal tissues is their daily hygiene. Oral hygiene techniques such brushing and a good interdental hygiene by correct flossing are very important. The aim of this study is to compare the use of dental floss in a loop vs traditional floss in the control of Loe-Silness Gingival Index (IG), Turesky´s Plaque Index (IPT), Gingival Bleeding Index (IS) and the values of interleukin 6 (IL-6) and interleukin 8 (IL-8). MATERIAL AND METHODS: A comparative study of 40 patients in which each patient was his own control, using during 45 days each one of the devices (new loop floss and conventional floss) of interdental hygiene analysed. Data for Loe-Silness Gingival Index (IG), Turesky´s Plaque Index (IPT), Gingival Bleeding Index (IS) and the values of interleukin 6 (IL-6) and interleukin 8 (IL-8)were collected and measured in every visit for every type of interdental hygiene device. RESULTS: Our data indicates that the rate of Turesky´s Plaque Index presented statistically significant differences between groups (loop: 1.66 ± 0.8; traditional: 1.12 ± 0.8; p<0.0001). The rest of the indices studied showed no statistically significant differences. CONCLUSIONS: The creation of new dental floss designs try to make their use easier and more sensitive, and plaque removal more effective. The loop design can facilitate interdental hygiene, reaching similar effectiveness than traditional floss, improving some indicators, such as Turesky´s Plaque Index. Key words:Dental floss, bacterial plaque, loop floss, plaque index, periodontal diseases. |
V, Torres-Lagares Gutierrez-Pérez JL Jimenez-Castellanos Torres-Sánchez Montoya-Salazar D E C Comparison of masticatory efficacy among complete denture wearers with two adhesives and dentate individuals: A randomized, crossover, double-blind clinical trial. Artículo de revista J Prosthet Dent., 2017. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{C2017, title = {Comparison of masticatory efficacy among complete denture wearers with two adhesives and dentate individuals: A randomized, crossover, double-blind clinical trial.}, author = {Torres-Lagares Gutierrez-Pérez JL Jimenez-Castellanos D E Torres-Sánchez C Montoya-Salazar V}, url = {https://www.ncbi.nlm.nih.gov/pmc/?term=28160588%5BPMID%5D&report=imagesdocsum}, doi = {10.1016/j.prosdent.2016.09.020}, year = {2017}, date = {2017-05-01}, journal = {J Prosthet Dent.}, abstract = {STATEMENT OF PROBLEM: The masticatory efficacy between dentate and edentulous individuals with and without the use of dental adhesives has been little studied. A comparative study of the addition of various agents of synthetic adhesion (vinyl methyl ether versus polyvinyl acetate) to these adhesives is needed. PURPOSE: The purpose of this randomized, crossover, double-blind clinical trial was to compare the masticatory efficacy of wearers of complete dentures with and without dental adhesives of 2 different compositions and that of dentate controls. MATERIAL AND METHODS: Seventeen participants with edentulism (edentulous control and 2 experimental groups) received new maxillary and mandibular complete dentures. After an adjustment period, they participated in masticatory tests with and without the use of 2 denture adhesives (Fittydent; Fittydent International GmbH and Corega; GlaxoSmithKline). The participants with edentulism were compared with 17 dentate controls. Masticatory efficacy was evaluated while the participants were masticating a substitute for irreversible hydrocolloid (20 g) and performing a single test of mastication (with 20 masticatory strokes) at 0, 7, and 14 days. Masticatory efficiency was measured immediately after each test with the sieving method and was calculated according to the weight of the particles of the substitute in each of the sieve filters. Data were analyzed using 1-way ANOVA for simple pairs, and a multiple comparison was made using the Wilcoxon test with Bonferroni correction (α=.05). RESULTS: Significant differences were found between the 2 adhesives (P<.05) in the masticatory efficacy for filters 2 and 3, and nonsignificant differences occurred for filter 1. Compared with the edentulous control group, significant differences between the use or nonuse of adhesives were found in the edentulous group for the 3 filters (P<.05). Compared with the dentate control group, significant differences were found in masticatory efficiency between the dentate control group and the other groups for all comparisons (P<.05). CONCLUSIONS: Masticatory efficacy was higher with the use of Corega denture adhesive. The masticatory efficacy was significantly higher in dentate participants compared with participants with edentulism who had complete dentures, with or without denture adhesives. A significant increase of masticatory efficacy was observed among edentulous participants with denture adhesives in relation to those not using denture adhesives.}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } STATEMENT OF PROBLEM: The masticatory efficacy between dentate and edentulous individuals with and without the use of dental adhesives has been little studied. A comparative study of the addition of various agents of synthetic adhesion (vinyl methyl ether versus polyvinyl acetate) to these adhesives is needed. PURPOSE: The purpose of this randomized, crossover, double-blind clinical trial was to compare the masticatory efficacy of wearers of complete dentures with and without dental adhesives of 2 different compositions and that of dentate controls. MATERIAL AND METHODS: Seventeen participants with edentulism (edentulous control and 2 experimental groups) received new maxillary and mandibular complete dentures. After an adjustment period, they participated in masticatory tests with and without the use of 2 denture adhesives (Fittydent; Fittydent International GmbH and Corega; GlaxoSmithKline). The participants with edentulism were compared with 17 dentate controls. Masticatory efficacy was evaluated while the participants were masticating a substitute for irreversible hydrocolloid (20 g) and performing a single test of mastication (with 20 masticatory strokes) at 0, 7, and 14 days. Masticatory efficiency was measured immediately after each test with the sieving method and was calculated according to the weight of the particles of the substitute in each of the sieve filters. Data were analyzed using 1-way ANOVA for simple pairs, and a multiple comparison was made using the Wilcoxon test with Bonferroni correction (α=.05). RESULTS: Significant differences were found between the 2 adhesives (P<.05) in the masticatory efficacy for filters 2 and 3, and nonsignificant differences occurred for filter 1. Compared with the edentulous control group, significant differences between the use or nonuse of adhesives were found in the edentulous group for the 3 filters (P<.05). Compared with the dentate control group, significant differences were found in masticatory efficiency between the dentate control group and the other groups for all comparisons (P<.05). CONCLUSIONS: Masticatory efficacy was higher with the use of Corega denture adhesive. The masticatory efficacy was significantly higher in dentate participants compared with participants with edentulism who had complete dentures, with or without denture adhesives. A significant increase of masticatory efficacy was observed among edentulous participants with denture adhesives in relation to those not using denture adhesives. |
A., Campano-Cuevas Castillo-Dalí Torres-Lagares Gutiérrez-Pérez Gutiérrez-Corrales E G D J L Ability of salivary biomarkers in the prognostic of systemic and buccal inflammation Artículo de revista J Clin Exp Dent., 9 (5), pp. e716-e722, 2017. Resumen | Enlaces | BibTeX | Etiquetas: publicaciones @article{Gutiérrez-Corrales2017, title = {Ability of salivary biomarkers in the prognostic of systemic and buccal inflammation}, author = {Campano-Cuevas Castillo-Dalí Torres-Lagares Gutiérrez-Pérez E G D J L Gutiérrez-Corrales A.}, doi = {10.4317/jced.53776}, year = {2017}, date = {2017-05-01}, journal = {J Clin Exp Dent.}, volume = {9}, number = {5}, pages = {e716-e722}, abstract = {Nowadays, there is a growing interest in using saliva as an alternative sample for the diagnosis, prediction and progression of several diseases. It has been established that some molecules found in saliva are related to oral inflammatory processes and systemic health status. Furthermore, it is known that saliva is crucial for the carrying out of different functions in the oral cavity and its role in the local modulation of inflammatory and immune response is being thoroughly studied by the health research community. The aim of this review is to analyze the most important biomarkers which have been utilized in biomedicine during the last two decades in order to establish a correlation between certain specific salivary biomarkers and systemic inflammation. Then, we discuss the utility of total proteins, immunoglobulin A and alpha-amylase as biomarkers for the prognostic of local inflammation after oral surgery. Key words:Inflammation, salivary biomarkers, systemic disease, buccal surgery, total proteins, inmunoglobulin A, Alpha-amylase.}, keywords = {publicaciones}, pubstate = {published}, tppubtype = {article} } Nowadays, there is a growing interest in using saliva as an alternative sample for the diagnosis, prediction and progression of several diseases. It has been established that some molecules found in saliva are related to oral inflammatory processes and systemic health status. Furthermore, it is known that saliva is crucial for the carrying out of different functions in the oral cavity and its role in the local modulation of inflammatory and immune response is being thoroughly studied by the health research community. The aim of this review is to analyze the most important biomarkers which have been utilized in biomedicine during the last two decades in order to establish a correlation between certain specific salivary biomarkers and systemic inflammation. Then, we discuss the utility of total proteins, immunoglobulin A and alpha-amylase as biomarkers for the prognostic of local inflammation after oral surgery. Key words:Inflammation, salivary biomarkers, systemic disease, buccal surgery, total proteins, inmunoglobulin A, Alpha-amylase. |
R, Batista-Cruzado López-Santos Rodríguez-González-Elipe Saffar JL Lynch CD Gutiérrez-Pérez JL Torres-Lagares Castillo-Dalí Castillo-Oyagüe A C A D G Reliability of new poly (lactic-co-glycolic acid) membranes treated with oxygen plasma plus silicon dioxide layers for pre-prosthetic guided bone regeneration processes. Artículo de revista Medicina Oral, Patología Oral Y Cirugía Bucal, 22 (2), pp. e242 - e250, 2017, ISSN: 1698-6946. Resumen | Enlaces | BibTeX | Etiquetas: @article{Castillo-Dalí2017e242, title = {Reliability of new poly (lactic-co-glycolic acid) membranes treated with oxygen plasma plus silicon dioxide layers for pre-prosthetic guided bone regeneration processes.}, author = {Batista-Cruzado López-Santos Rodríguez-González-Elipe Saffar JL Lynch CD Gutiérrez-Pérez JL Torres-Lagares A C A D Castillo-Dalí G Castillo-Oyagüe R}, url = {https://www.ncbi.nlm.nih.gov/pubmed/?term=Reliability+of+new+poly+(lactic-co-glycolic+acid)+membranes+treated+with+oxygen+plasma+plus+silicon+dioxide+layers+for+pre-prosthetic+guided+bone+regeneration+processes.}, doi = {10.4317/medoral.21512}, issn = {1698-6946}, year = {2017}, date = {2017-03-01}, journal = {Medicina Oral, Patología Oral Y Cirugía Bucal}, volume = {22}, number = {2}, pages = {e242 - e250}, abstract = {BACKGROUND: The use of cold plasmas may improve the surface roughness of poly(lactic-co-glycolic) acid (PLGA) membranes, which may stimulate the adhesion of osteogenic mediators and cells, thus accelerating the biodegradation of the barriers. Moreover, the incorporation of metallic-oxide particles to the surface of these membranes may enhance their osteoinductive capacity. Therefore, the aim of this paper was to evaluate the reliability of a new PLGA membrane after being treated with oxygen plasma (PO2) plus silicon dioxide (SiO2) layers for guided bone regeneration (GBR) processes. MATERIAL AND METHODS: Circumferential bone defects (diameter: 11 mm; depth: 3 mm) were created on the top of eight experimentation rabbits' skulls and were randomly covered with: (1) PLGA membranes (control), or (2) PLGA/PO2/SiO2 barriers. The animals were euthanized two months afterwards. A micromorphologic study was then performed using ROI (region of interest) colour analysis. Percentage of new bone formation, length of mineralised bone, concentration of osteoclasts, and intensity of ostheosynthetic activity were assessed and compared with those of the original bone tissue. The Kruskal-Wallis test was applied for between-group com Asignificance level of a=0.05 was considered. RESULTS: The PLGA/PO2/SiO2 membranes achieved the significantly highest new bone formation, length of mineralised bone, concentration of osteoclasts, and ostheosynthetic activity. The percentage of regenerated bone supplied by the new membranes was similar to that of the original bone tissue. Unlike what happened in the control group, PLGA/PO2/SiO2 membranes predominantly showed bone layers in advanced stages of formation. CONCLUSIONS: The addition of SiO2 layers to PLGA membranes pre-treated with PO2 improves their bone-regeneration potential. Although further research is necessary to corroborate these conclusions in humans, this could be a promising strategy to rebuild the bone architecture prior to rehabilitate edentulous areas.}, keywords = {}, pubstate = {published}, tppubtype = {article} } BACKGROUND: The use of cold plasmas may improve the surface roughness of poly(lactic-co-glycolic) acid (PLGA) membranes, which may stimulate the adhesion of osteogenic mediators and cells, thus accelerating the biodegradation of the barriers. Moreover, the incorporation of metallic-oxide particles to the surface of these membranes may enhance their osteoinductive capacity. Therefore, the aim of this paper was to evaluate the reliability of a new PLGA membrane after being treated with oxygen plasma (PO2) plus silicon dioxide (SiO2) layers for guided bone regeneration (GBR) processes. MATERIAL AND METHODS: Circumferential bone defects (diameter: 11 mm; depth: 3 mm) were created on the top of eight experimentation rabbits' skulls and were randomly covered with: (1) PLGA membranes (control), or (2) PLGA/PO2/SiO2 barriers. The animals were euthanized two months afterwards. A micromorphologic study was then performed using ROI (region of interest) colour analysis. Percentage of new bone formation, length of mineralised bone, concentration of osteoclasts, and intensity of ostheosynthetic activity were assessed and compared with those of the original bone tissue. The Kruskal-Wallis test was applied for between-group com Asignificance level of a=0.05 was considered. RESULTS: The PLGA/PO2/SiO2 membranes achieved the significantly highest new bone formation, length of mineralised bone, concentration of osteoclasts, and ostheosynthetic activity. The percentage of regenerated bone supplied by the new membranes was similar to that of the original bone tissue. Unlike what happened in the control group, PLGA/PO2/SiO2 membranes predominantly showed bone layers in advanced stages of formation. CONCLUSIONS: The addition of SiO2 layers to PLGA membranes pre-treated with PO2 improves their bone-regeneration potential. Although further research is necessary to corroborate these conclusions in humans, this could be a promising strategy to rebuild the bone architecture prior to rehabilitate edentulous areas. |
Diaz-Sanchez, Rosa-Maria; Delgado-Muñoz, Jose-Maria; Hita-Iglesias, Pilar; Pullen, Kyle T; Serrera-Figallo, Maria-Angeles; Torres-Lagares, Daniel Improvement in the initial ISQ through use of a modified surgical technique. Artículo de revista The Journal Of Oral Implantology, 2017, ISSN: 1548-1336. Resumen | Enlaces | BibTeX | Etiquetas: @article{2821886620170220, title = {Improvement in the initial ISQ through use of a modified surgical technique.}, author = {Rosa-Maria Diaz-Sanchez and Jose-Maria Delgado-Muñoz and Pilar Hita-Iglesias and Kyle T Pullen and Maria-Angeles Serrera-Figallo and Daniel Torres-Lagares}, url = {https://www.ncbi.nlm.nih.gov/pubmed/?term=Improvement+in+the+initial+ISQ+through+use+of+a+modified+surgical+technique.}, doi = {10.1563/aaid-joi-D-16-00159.}, issn = {1548-1336}, year = {2017}, date = {2017-02-01}, journal = {The Journal Of Oral Implantology}, abstract = {To ensure that similar primary implant stability measured by resonance frequency analysis (RFA) could be obtained in different jawbone densities by using a specific surgical drilling protocol and, to correlate those RFA measurements with factors related to the implant design, width and length, we are performed a one-year prospective clinical study was carried out using 27 subjects. A total of 67 hydrophilic titanium implants were placed using a standard two-stage implant placement protocol. The bone type at each implant site was determined by evaluation of a preoperative, high-resolution cone beam computed tomography (CBCT) scan. A modified drilling protocol was used in softer bone (types 2, 3 and 4) that allowed for greater implant thread contact with the surrounding bone. The implant stability quotient (ISQ) was measured at four different times during the study: initially it was determined immediately after implant placement, then again at stage two uncovering surgery, then at six months' post-placement and, and finally at one-year post-placement. Data collected immediately after implant surgery demonstrated a high correlation (R2=0.99) between the ISQ and bone type classification. An overall trend towards a higher ISQ was found over the one-year study period for all types of bone. Implants remained clinically and radiographically stable during the one-year study period. Our data allow conclude that the primary stability of two-staged loaded implants placed in different bone types can be optimized by applying this surgical drilling protocol during the implant placement. The ISQ method was found to be a reliable predictor of implant stability.}, keywords = {}, pubstate = {published}, tppubtype = {article} } To ensure that similar primary implant stability measured by resonance frequency analysis (RFA) could be obtained in different jawbone densities by using a specific surgical drilling protocol and, to correlate those RFA measurements with factors related to the implant design, width and length, we are performed a one-year prospective clinical study was carried out using 27 subjects. A total of 67 hydrophilic titanium implants were placed using a standard two-stage implant placement protocol. The bone type at each implant site was determined by evaluation of a preoperative, high-resolution cone beam computed tomography (CBCT) scan. A modified drilling protocol was used in softer bone (types 2, 3 and 4) that allowed for greater implant thread contact with the surrounding bone. The implant stability quotient (ISQ) was measured at four different times during the study: initially it was determined immediately after implant placement, then again at stage two uncovering surgery, then at six months' post-placement and, and finally at one-year post-placement. Data collected immediately after implant surgery demonstrated a high correlation (R2=0.99) between the ISQ and bone type classification. An overall trend towards a higher ISQ was found over the one-year study period for all types of bone. Implants remained clinically and radiographically stable during the one-year study period. Our data allow conclude that the primary stability of two-staged loaded implants placed in different bone types can be optimized by applying this surgical drilling protocol during the implant placement. The ISQ method was found to be a reliable predictor of implant stability. |
E, Castillo-Dalí Serrera-Figallo Torres-Lagares Gutiérrez-Pérez JL. Gutiérrez-Corrales Campano-Cuevas G MÁ D A Relationship between salivary biomarkers and postoperative swelling after the extraction of impacted lower third molars. Artículo de revista International Journal of Oral & Maxillofacial Surgery, 46 , pp. 243 - 249, 2017, ISSN: 0901-5027. Resumen | Enlaces | BibTeX | Etiquetas: @article{Gutiérrez-Corrales2017243, title = {Relationship between salivary biomarkers and postoperative swelling after the extraction of impacted lower third molars.}, author = {Castillo-Dalí Serrera-Figallo Torres-Lagares Gutiérrez-Pérez JL. G MÁ D Gutiérrez-Corrales A Campano-Cuevas E}, editor = {Elsevier Ltd}, url = {https://www.ncbi.nlm.nih.gov/pubmed/?term=Relationship+between+salivary+biomarkers+and+postoperative+swelling+after+the+extraction+of+impacted+lower+third+molars.}, doi = {10.1016/j.ijom.2016.10.005}, issn = {0901-5027}, year = {2017}, date = {2017-02-01}, journal = {International Journal of Oral & Maxillofacial Surgery}, volume = {46}, pages = {243 - 249}, abstract = {Many authors have studied various different parameters in relation to postoperative anxiety after the extraction of third molars. However, the effect that the acute inflammatory process occurring post extraction could have on these parameters has not been studied. Certain salivary biomarkers, although not specifically inflammatory, may be affected by the acute inflammatory process occurring following the extraction of a retained lower third molar. Three biomarkers were assessed in this study: total protein, immunoglobulin A (IgA), and alpha-amylase. A total of 15 patients were recruited. Four samples of saliva were taken from each patient: before extraction, immediately after extraction, at 2h after extraction, and at 7 days after extraction. The concentrations of the proteins in the saliva were measured. The average values of each marker were compared across the different stages of the study. Statistical analysis revealed that of the three salivary biomarkers, only alpha-amylase was associated with an inflammatory response to the surgery (P<0.05). These results suggest the possibility that salivary alpha-amylase levels may be affected by the acute inflammation occurring post extraction; therefore, this would not be an appropriate marker to use in the study of other situations, unless this interference is controlled for.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Many authors have studied various different parameters in relation to postoperative anxiety after the extraction of third molars. However, the effect that the acute inflammatory process occurring post extraction could have on these parameters has not been studied. Certain salivary biomarkers, although not specifically inflammatory, may be affected by the acute inflammatory process occurring following the extraction of a retained lower third molar. Three biomarkers were assessed in this study: total protein, immunoglobulin A (IgA), and alpha-amylase. A total of 15 patients were recruited. Four samples of saliva were taken from each patient: before extraction, immediately after extraction, at 2h after extraction, and at 7 days after extraction. The concentrations of the proteins in the saliva were measured. The average values of each marker were compared across the different stages of the study. Statistical analysis revealed that of the three salivary biomarkers, only alpha-amylase was associated with an inflammatory response to the surgery (P<0.05). These results suggest the possibility that salivary alpha-amylase levels may be affected by the acute inflammation occurring post extraction; therefore, this would not be an appropriate marker to use in the study of other situations, unless this interference is controlled for. |
MÁ, Gutiérrez-Corrales Romero-Ruiz MM Castillo-de-Oyagüe Gutiérrez-Pérez JL Machuca-Portillo Torres-Lagares Bermúdez-Bejarano EB Serrera-Figallo A R G D Analysis of different therapeutic protocols for osteonecrosis of the jaw associated with oral and intravenous bisphosphonates. Artículo de revista Medicina Oral, Patologia Oral Y Cirugia Bucal, 22 (1), pp. e43 - e57, 2017, ISSN: 1698-6946. Resumen | Enlaces | BibTeX | Etiquetas: @article{Bermúdez-Bejarano2017e43, title = {Analysis of different therapeutic protocols for osteonecrosis of the jaw associated with oral and intravenous bisphosphonates.}, author = {Gutiérrez-Corrales Romero-Ruiz MM Castillo-de-Oyagüe Gutiérrez-Pérez JL Machuca-Portillo Torres-Lagares A R G D Bermúdez-Bejarano EB Serrera-Figallo MÁ}, url = {https://www.ncbi.nlm.nih.gov/pubmed/?term=Analysis+of+different+therapeutic+protocols+for+osteonecrosis+of+the+jaw+associated+with+oral+and+intravenous+bisphosphonates.}, doi = {10.4317/medoral.21477}, issn = {1698-6946}, year = {2017}, date = {2017-01-01}, journal = {Medicina Oral, Patologia Oral Y Cirugia Bucal}, volume = {22}, number = {1}, pages = {e43 - e57}, abstract = {INTRODUCTION: Chemotherapy-associated osteonecrosis of the jaw caused by bisphosphonates is an exposure of necrotic bone with more than eight weeks of evolution that is attributable to bisphosphonates and no prior radiation therapy. Its etiopathogenesis remains unknown, although there are two hypotheses that may explain it: the drug's mechanism of action, and the risk factors that can lead to osteonecrosis. There is a wide range of treatment options for managing chemotherapy-associated osteonecrosis of the jaw, from conservative treatments to surgical procedures of varying levels of invasiveness, which are sometimes supplemented with adjuvant therapies. OBJECTIVE: The objective of this article is to group the therapeutic options for osteonecrosis of the jaw (ONJ) into seven different protocols and to evaluate their effectiveness in relation to stage of ONJ. MATERIAL AND METHODS: A literature review was carried out in PubMed following the PRISMA criteria. A total of 47 were collected after compiling a series of variables that define ONJ, applied treatments, and the clinical results obtained. RESULTS AND DISCUSSION: The 47 articles selected have a low to average estimated risk of bias and are of moderate to good quality. According to the data obtained, Protocol 3 (conservative treatment, clinical and radiological follow-up, minimally invasive surgical treatment, and adjuvant therapies) is the most favorable approach for ONJ lesions caused by oral bisphosphonates. For lesions caused by intravenous bisphosphonates, Protocol 2 (conservative treatment, clinical and radiological follow-up, minimally invasive surgical treatment, and no adjuvant therapies) is the best approach. When comparing the different stages of ONJ, Protocol 1 (conservative treatment, clinical and radiological follow-up) promotes better healing of Stage 1 ONJ lesions caused by orally administered bisphosphonates, and Protocol 3 is recommended for Stage II. For ONJ lesions attributable to intravenous bisphosphonates, Protocol 7 (conservative treatment, clinical and radiological follow-up, and adjuvant therapies) provides the best results in Stage 0; in Stages I, II, and III, Protocol 1 gives better results.}, keywords = {}, pubstate = {published}, tppubtype = {article} } INTRODUCTION: Chemotherapy-associated osteonecrosis of the jaw caused by bisphosphonates is an exposure of necrotic bone with more than eight weeks of evolution that is attributable to bisphosphonates and no prior radiation therapy. Its etiopathogenesis remains unknown, although there are two hypotheses that may explain it: the drug's mechanism of action, and the risk factors that can lead to osteonecrosis. There is a wide range of treatment options for managing chemotherapy-associated osteonecrosis of the jaw, from conservative treatments to surgical procedures of varying levels of invasiveness, which are sometimes supplemented with adjuvant therapies. OBJECTIVE: The objective of this article is to group the therapeutic options for osteonecrosis of the jaw (ONJ) into seven different protocols and to evaluate their effectiveness in relation to stage of ONJ. MATERIAL AND METHODS: A literature review was carried out in PubMed following the PRISMA criteria. A total of 47 were collected after compiling a series of variables that define ONJ, applied treatments, and the clinical results obtained. RESULTS AND DISCUSSION: The 47 articles selected have a low to average estimated risk of bias and are of moderate to good quality. According to the data obtained, Protocol 3 (conservative treatment, clinical and radiological follow-up, minimally invasive surgical treatment, and adjuvant therapies) is the most favorable approach for ONJ lesions caused by oral bisphosphonates. For lesions caused by intravenous bisphosphonates, Protocol 2 (conservative treatment, clinical and radiological follow-up, minimally invasive surgical treatment, and no adjuvant therapies) is the best approach. When comparing the different stages of ONJ, Protocol 1 (conservative treatment, clinical and radiological follow-up) promotes better healing of Stage 1 ONJ lesions caused by orally administered bisphosphonates, and Protocol 3 is recommended for Stage II. For ONJ lesions attributable to intravenous bisphosphonates, Protocol 7 (conservative treatment, clinical and radiological follow-up, and adjuvant therapies) provides the best results in Stage 0; in Stages I, II, and III, Protocol 1 gives better results. |
MÁ, Gutiérrez-Corrales Romero-Ruiz MM Castillo-de-Oyagüe Gutiérrez-Pérez JL Torres-Lagares Bermúdez-Bejarano EB Serrera-Figallo A R D Prophylaxis and antibiotic therapy in management protocols of patients treated with oral and intravenous bisphosphonates. Artículo de revista Journal of Clinical and Experimental Dentistry, 9 (1), pp. e141-e149, 2017, ISSN: 19895488. Resumen | Enlaces | BibTeX | Etiquetas: @article{Bermúdez-Bejarano2017e141, title = {Prophylaxis and antibiotic therapy in management protocols of patients treated with oral and intravenous bisphosphonates.}, author = {Gutiérrez-Corrales Romero-Ruiz MM Castillo-de-Oyagüe Gutiérrez-Pérez JL Torres-Lagares A R D Bermúdez-Bejarano EB Serrera-Figallo MÁ}, url = {https://www.ncbi.nlm.nih.gov/pubmed/?term=Prophylaxis+and+antibiotic+therapy+in+management+protocols+of+patients+treated+with+oral+and+intravenous+bisphosphonates.}, doi = {10.4317/jced.53372.}, issn = {19895488}, year = {2017}, date = {2017-01-01}, journal = {Journal of Clinical and Experimental Dentistry}, volume = {9}, number = {1}, pages = {e141-e149}, abstract = {INTRODUCTION: Osteonecrosis of the jaw (MRONJ) linked to bisphosphonate treatment has specific characteristics that render its therapeutic management challenging for clinicians. Poor response to standard treatment makes it essential to take special precautions when treating this type of disease; therefore, antibiotic prophylaxis and/or antibiotic therapy have been proposed as effective and helpful tools in these situations. OBJECTIVES: This article seeks to assess published evidence in order to evaluate the different protocols used for antibiotic prophylaxis and/or antibiotic therapy in the general context of patients treated with bisphosphonates. MATERIAL AND METHODS: A literature review of the last 10 years was carried out in PubMed using the following keywords: "antibiotic prophylaxis and osteonecrosis," "bisphosphonates AND osteonecrosis AND dental management," "bisphosphonate AND osteonecrosis AND antibiotic prophylaxis AND oral surgery." A total of 188 articles were obtained, of which 18 were ultimately selected. RESULTS AND DISCUSSION: In patients treated with oral and intravenous bisphosphonates without chemotherapy-associated osteonecrosis of the jaw, antibiotic prophylaxis prior to oral surgery is an important tool to avoid osteonecrosis and promote healing of the affected area. If the patient previously exhibited chemotherapy-associated osteonecrosis after tooth extraction, antibiotic prophylaxis is indicated to prevent recurrent osteonecrosis and promote healing of the extraction site. If chemotherapy-associated osteonecrosis is already present, antibiotic therapy is a vital part of conservative management to reduce the symptomatology of MRONJ and keep it from worsening. Finally, a lack of clinical data and randomized controlled trials makes it difficult to choose the most appropriate protocol for the various clinical situations studied. Key words:Bisphosphonates, antibiotic prophylaxis, maxillary osteonecrosis, antibiotic treatment.}, keywords = {}, pubstate = {published}, tppubtype = {article} } INTRODUCTION: Osteonecrosis of the jaw (MRONJ) linked to bisphosphonate treatment has specific characteristics that render its therapeutic management challenging for clinicians. Poor response to standard treatment makes it essential to take special precautions when treating this type of disease; therefore, antibiotic prophylaxis and/or antibiotic therapy have been proposed as effective and helpful tools in these situations. OBJECTIVES: This article seeks to assess published evidence in order to evaluate the different protocols used for antibiotic prophylaxis and/or antibiotic therapy in the general context of patients treated with bisphosphonates. MATERIAL AND METHODS: A literature review of the last 10 years was carried out in PubMed using the following keywords: "antibiotic prophylaxis and osteonecrosis," "bisphosphonates AND osteonecrosis AND dental management," "bisphosphonate AND osteonecrosis AND antibiotic prophylaxis AND oral surgery." A total of 188 articles were obtained, of which 18 were ultimately selected. RESULTS AND DISCUSSION: In patients treated with oral and intravenous bisphosphonates without chemotherapy-associated osteonecrosis of the jaw, antibiotic prophylaxis prior to oral surgery is an important tool to avoid osteonecrosis and promote healing of the affected area. If the patient previously exhibited chemotherapy-associated osteonecrosis after tooth extraction, antibiotic prophylaxis is indicated to prevent recurrent osteonecrosis and promote healing of the extraction site. If chemotherapy-associated osteonecrosis is already present, antibiotic therapy is a vital part of conservative management to reduce the symptomatology of MRONJ and keep it from worsening. Finally, a lack of clinical data and randomized controlled trials makes it difficult to choose the most appropriate protocol for the various clinical situations studied. Key words:Bisphosphonates, antibiotic prophylaxis, maxillary osteonecrosis, antibiotic treatment. |
ML, Alberdi-Navarro Cabezas-Talavero Romero-Ruiz MM Torres-Lagares Aguirre-Urizar JM Gutiérrez-Pérez JL. Vázquez-Romero MD Serrera-Figallo J J D Maxillary peripheral keratocystic odontogenic tumor. A clinical case report. Artículo de revista Journal of Clinical and Experimental Dentistry, 9 (1), pp. e167-e171, 2017, ISSN: 19895488. Resumen | Enlaces | BibTeX | Etiquetas: @article{Vázquez-Romero2017e167, title = {Maxillary peripheral keratocystic odontogenic tumor. A clinical case report.}, author = {Alberdi-Navarro Cabezas-Talavero Romero-Ruiz MM Torres-Lagares Aguirre-Urizar JM Gutiérrez-Pérez JL. J J D Vázquez-Romero MD Serrera-Figallo ML}, url = {https://www.ncbi.nlm.nih.gov/pubmed/28149484}, doi = {10.4317/jced.53438}, issn = {19895488}, year = {2017}, date = {2017-01-01}, journal = {Journal of Clinical and Experimental Dentistry}, volume = {9}, number = {1}, pages = {e167-e171}, abstract = {The keratocystic odontogenic tumor is a benign odontogenic cystic neoplasia characterized by its thin, squamous epithelium with superficial parakeratosis. It has the potential for infiltration and local aggressiveness and has a high rate of recurrence. This neoplasia is predominantly found in males and people of white origin. The mandible is the most frequently involved site, in particular the third molar region, mandibular angle, and ramus. It has a mandible-maxilla ratio of 2:1. Only about twenty cases of peripheral keratocystic odontogenic tumors (PKCOT) have been reported in the international literature. This study presents a case of PKCOT localized in the anterior region of the maxilla, on the vestibular side of the upper left lateral incisor and the upper left canine. The diagnosis and treatment procedures, as based on the literature, are also discussed. Key words:Odontogenic cysts, odontogenic tumors, keratocyst, keratocystic odontogenic tumor.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The keratocystic odontogenic tumor is a benign odontogenic cystic neoplasia characterized by its thin, squamous epithelium with superficial parakeratosis. It has the potential for infiltration and local aggressiveness and has a high rate of recurrence. This neoplasia is predominantly found in males and people of white origin. The mandible is the most frequently involved site, in particular the third molar region, mandibular angle, and ramus. It has a mandible-maxilla ratio of 2:1. Only about twenty cases of peripheral keratocystic odontogenic tumors (PKCOT) have been reported in the international literature. This study presents a case of PKCOT localized in the anterior region of the maxilla, on the vestibular side of the upper left lateral incisor and the upper left canine. The diagnosis and treatment procedures, as based on the literature, are also discussed. Key words:Odontogenic cysts, odontogenic tumors, keratocyst, keratocystic odontogenic tumor. |
2016 |
Stambolsky, Carlos; Rodríguez-Benítez, Soledad; Gutiérrez-Pérez, José Luis; Torres-Lagares, Daniel; Martín-González, Jenifer; Segura-Egea, Juan José Histologic characterization of regenerated tissues after pulp revascularization of immature dog teeth with apical periodontitis using tri-antibiotic paste and platelet-rich plasma. Artículo de revista Archives of Oral Biology, 71 , pp. 122 - 128, 2016, ISSN: 0003-9969. Resumen | Enlaces | BibTeX | Etiquetas: @article{Stambolsky2016122b, title = {Histologic characterization of regenerated tissues after pulp revascularization of immature dog teeth with apical periodontitis using tri-antibiotic paste and platelet-rich plasma.}, author = {Carlos Stambolsky and Soledad Rodríguez-Benítez and José Luis Gutiérrez-Pérez and Daniel Torres-Lagares and Jenifer Martín-González and Juan José Segura-Egea}, editor = {Elsevier Ltd}, url = {https://www.ncbi.nlm.nih.gov/pubmed/?term=Histologic+characterization+of+regenerated+tissues+after+pulp+revascularization+of+immature+dog+teeth+with+apical+periodontitis+using+tri-antibiotic+paste+and+platelet-rich+plasma.}, doi = {10.1016/j.archoralbio.2016.07.007}, issn = {0003-9969}, year = {2016}, date = {2016-11-01}, journal = {Archives of Oral Biology}, volume = {71}, pages = {122 - 128}, abstract = {INTRODUCTION: This study evaluates histologically the efficacy of 4 revascularization protocols in necrotic-infected immature dog teeth with apical periodontitis (AP). METHODS: Forty double-rooted immature premolar teeth from 4 female Beagle dogs aged 5 months were used. Four teeth were left untouched as negative controls; the other 36 teeth were infected to develop pulp necrosis and AP. Four teeth were left untreated and assigned to the positive control group. The last 28 teeth were randomly assigned into four experimental groups of 8 teeth, each one treated with a different treatment protocol: A1, sodium hypochlorite (SH)+blood clot (BC); A2, SH+platelet-rich plasma (PRP); B1, SH+modified tri-antibiotic paste (mTAP)+BC; B2, SH+mTAP+PRP. The animals were sacrificed, histologic sections were prepared and three parameters were assessed: (1) presence or absence of new hard tissue on the internal root dentinal walls, (2) presence or absence of continued apical closure, and (3) presence or absence of vital tissue within the canal space. RESULTS: Significant differences (p<0.05) between the four experimental groups were evident in the percentage of teeth showing histological apical closure (34.5%) and vital tissue within the canal space (68.8%). Group B2 showed the maximal improvement in the three variables assessed (p<0.05). Group A1 showed the minimum percentages in the three parameters assessed (p<0.05). CONCLUSIONS: These results suggest that an intracanal dressing of mTAP, and the use of PRP as scaffold, improves the success rate of the revascularization procedure.}, keywords = {}, pubstate = {published}, tppubtype = {article} } INTRODUCTION: This study evaluates histologically the efficacy of 4 revascularization protocols in necrotic-infected immature dog teeth with apical periodontitis (AP). METHODS: Forty double-rooted immature premolar teeth from 4 female Beagle dogs aged 5 months were used. Four teeth were left untouched as negative controls; the other 36 teeth were infected to develop pulp necrosis and AP. Four teeth were left untreated and assigned to the positive control group. The last 28 teeth were randomly assigned into four experimental groups of 8 teeth, each one treated with a different treatment protocol: A1, sodium hypochlorite (SH)+blood clot (BC); A2, SH+platelet-rich plasma (PRP); B1, SH+modified tri-antibiotic paste (mTAP)+BC; B2, SH+mTAP+PRP. The animals were sacrificed, histologic sections were prepared and three parameters were assessed: (1) presence or absence of new hard tissue on the internal root dentinal walls, (2) presence or absence of continued apical closure, and (3) presence or absence of vital tissue within the canal space. RESULTS: Significant differences (p<0.05) between the four experimental groups were evident in the percentage of teeth showing histological apical closure (34.5%) and vital tissue within the canal space (68.8%). Group B2 showed the maximal improvement in the three variables assessed (p<0.05). Group A1 showed the minimum percentages in the three parameters assessed (p<0.05). CONCLUSIONS: These results suggest that an intracanal dressing of mTAP, and the use of PRP as scaffold, improves the success rate of the revascularization procedure. |
Á, Serrera-Figallo Garrido-Serrano Gutiérrez-Corrales Gutiérrez-Pérez JL Torres-Lagares Madrazo-Jiménez Rodríguez-Caballero MÁ R A D M The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction. Artículo de revista Medicina Oral, Patologia Oral y Cirugia Bucal, 21 (6), pp. e696–e702, 2016, ISSN: 16986946. Resumen | Enlaces | BibTeX | Etiquetas: @article{Madrazo-Jiménez2016e696, title = {The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction.}, author = {Serrera-Figallo Garrido-Serrano Gutiérrez-Corrales Gutiérrez-Pérez JL Torres-Lagares MÁ R A D Madrazo-Jiménez M Rodríguez-Caballero Á}, editor = {Patologia Oral Cirugia Bucal y Medicina Oral}, url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116111/}, doi = {10.4317/medoral.21281}, issn = {16986946}, year = {2016}, date = {2016-11-01}, journal = {Medicina Oral, Patologia Oral y Cirugia Bucal}, volume = {21}, number = {6}, pages = {e696–e702}, abstract = {Background: Despite efforts to prevent postoperative discomfort, there are still many immediate side effects associated with the surgical extraction of impacted lower third molars. Cicatrization is a physiological process through which the loss of integrity of oral mucosa is recovered and damaged tissues are repaired. Bexident Post (ISDIN, Spain) is a topical gel that contains chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol. While this gel has many clinical indications, there are no published clinical trials evaluating its use in impacted mandibular third molar surgery. This study aims to clinically evaluate the efficacy of a gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol on wound healing and reduction of postoperative side effects and complications after extraction of an impacted mandibular third molar. Material and Methods: A split-mouth design study was carried out on a total of 50 bilaterally and symmetrically impacted third molar extractions, which were randomly placed into either a control group (CG=25) or an experimental group (EG=25). Patients were all informed of the purpose of the study and provided written consent. All procedures were carried out by the same dental practitioner, in accordance with standard surgical protocol. A different dental practitioner, unaware of which treatment had been applied, provided follow-up care. The EG applied 10 ml of topical gel composed of chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol to the surgical wound three times a day for 10 days, patients in the CG did not apply any gel. Results: The groups were homogeneous insofar as potentially confounding variables. No significant findings were found regarding postoperative swelling and pain. Neither of the groups displayed poor healing or infectious complications of the wound during the postoperative period. In all the recorded follow-ups (Day 7 p=0.001, and Day 14 p=0.01), the wound’s aesthetic appearance was better in the EG. Overall treatment tolerance was satisfactory and similar in both groups. Conclusions: The gel composed of chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not aid in patients’ postoperative comfort; however, improved wound healing was observed. © Medicina Oral S. L. C.I.F. B.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Background: Despite efforts to prevent postoperative discomfort, there are still many immediate side effects associated with the surgical extraction of impacted lower third molars. Cicatrization is a physiological process through which the loss of integrity of oral mucosa is recovered and damaged tissues are repaired. Bexident Post (ISDIN, Spain) is a topical gel that contains chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol. While this gel has many clinical indications, there are no published clinical trials evaluating its use in impacted mandibular third molar surgery. This study aims to clinically evaluate the efficacy of a gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol on wound healing and reduction of postoperative side effects and complications after extraction of an impacted mandibular third molar. Material and Methods: A split-mouth design study was carried out on a total of 50 bilaterally and symmetrically impacted third molar extractions, which were randomly placed into either a control group (CG=25) or an experimental group (EG=25). Patients were all informed of the purpose of the study and provided written consent. All procedures were carried out by the same dental practitioner, in accordance with standard surgical protocol. A different dental practitioner, unaware of which treatment had been applied, provided follow-up care. The EG applied 10 ml of topical gel composed of chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol to the surgical wound three times a day for 10 days, patients in the CG did not apply any gel. Results: The groups were homogeneous insofar as potentially confounding variables. No significant findings were found regarding postoperative swelling and pain. Neither of the groups displayed poor healing or infectious complications of the wound during the postoperative period. In all the recorded follow-ups (Day 7 p=0.001, and Day 14 p=0.01), the wound’s aesthetic appearance was better in the EG. Overall treatment tolerance was satisfactory and similar in both groups. Conclusions: The gel composed of chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not aid in patients’ postoperative comfort; however, improved wound healing was observed. © Medicina Oral S. L. C.I.F. B. |
V, Torres-Lagares Gutierrez-Pérez JL Jimenez-Castellanos Torres-Sánchez Montoya-Salazar D E C Comparison of masticatory efficacy among complete denture wearers with two adhesives and dentate individuals: A randomized, crossover, double-blind clinical trial. Artículo de revista The Journal of Prosthetic Dentistry, 2016, ISSN: 0022-3913. Resumen | Enlaces | BibTeX | Etiquetas: @article{Torres-Sánchez2016, title = {Comparison of masticatory efficacy among complete denture wearers with two adhesives and dentate individuals: A randomized, crossover, double-blind clinical trial.}, author = {Torres-Lagares Gutierrez-Pérez JL Jimenez-Castellanos D E Torres-Sánchez C Montoya-Salazar V}, editor = {Elsevier Inc.}, url = {https://www.ncbi.nlm.nih.gov/pubmed/?term=Comparison+of+masticatory+efficacy+among+complete+denture+wearers+with+two+adhesives+and+dentate+individuals%3A+A+randomized%2C+crossover%2C+double-blind+clinical+trial}, doi = {10.1016/j.prosdent.2016.09.020}, issn = {0022-3913}, year = {2016}, date = {2016-11-01}, journal = {The Journal of Prosthetic Dentistry}, abstract = {STATEMENT OF PROBLEM: The masticatory efficacy between dentate and edentulous individuals with and without the use of dental adhesives has been little studied. A comparative study of the addition of various agents of synthetic adhesion (vinyl methyl ether versus polyvinyl acetate) to these adhesives is needed. PURPOSE: The purpose of this randomized, crossover, double-blind clinical trial was to compare the masticatory efficacy of wearers of complete dentures with and without dental adhesives of 2 different compositions and that of dentate controls. MATERIAL AND METHODS: Seventeen participants with edentulism (edentulous control and 2 experimental groups) received new maxillary and mandibular complete dentures. After an adjustment period, they participated in masticatory tests with and without the use of 2 denture adhesives (Fittydent; Fittydent International GmbH and Corega; GlaxoSmithKline). The participants with edentulism were compared with 17 dentate controls. Masticatory efficacy was evaluated while the participants were masticating a substitute for irreversible hydrocolloid (20 g) and performing a single test of mastication (with 20 masticatory strokes) at 0, 7, and 14 days. Masticatory efficiency was measured immediately after each test with the sieving method and was calculated according to the weight of the particles of the substitute in each of the sieve filters. Data were analyzed using 1-way ANOVA for simple pairs, and a multiple comparison was made using the Wilcoxon test with Bonferroni correction (α=.05). RESULTS: Significant differences were found between the 2 adhesives (P<.05) in the masticatory efficacy for filters 2 and 3, and nonsignificant differences occurred for filter 1. Compared with the edentulous control group, significant differences between the use or nonuse of adhesives were found in the edentulous group for the 3 filters (P<.05). Compared with the dentate control group, significant differences were found in masticatory efficiency between the dentate control group and the other groups for all comparisons (P<.05). CONCLUSIONS: Masticatory efficacy was higher with the use of Corega denture adhesive. The masticatory efficacy was significantly higher in dentate participants compared with participants with edentulism who had complete dentures, with or without denture adhesives. A significant increase of masticatory efficacy was observed among edentulous participants with denture adhesives in relation to those not using denture adhesives.}, keywords = {}, pubstate = {published}, tppubtype = {article} } STATEMENT OF PROBLEM: The masticatory efficacy between dentate and edentulous individuals with and without the use of dental adhesives has been little studied. A comparative study of the addition of various agents of synthetic adhesion (vinyl methyl ether versus polyvinyl acetate) to these adhesives is needed. PURPOSE: The purpose of this randomized, crossover, double-blind clinical trial was to compare the masticatory efficacy of wearers of complete dentures with and without dental adhesives of 2 different compositions and that of dentate controls. MATERIAL AND METHODS: Seventeen participants with edentulism (edentulous control and 2 experimental groups) received new maxillary and mandibular complete dentures. After an adjustment period, they participated in masticatory tests with and without the use of 2 denture adhesives (Fittydent; Fittydent International GmbH and Corega; GlaxoSmithKline). The participants with edentulism were compared with 17 dentate controls. Masticatory efficacy was evaluated while the participants were masticating a substitute for irreversible hydrocolloid (20 g) and performing a single test of mastication (with 20 masticatory strokes) at 0, 7, and 14 days. Masticatory efficiency was measured immediately after each test with the sieving method and was calculated according to the weight of the particles of the substitute in each of the sieve filters. Data were analyzed using 1-way ANOVA for simple pairs, and a multiple comparison was made using the Wilcoxon test with Bonferroni correction (α=.05). RESULTS: Significant differences were found between the 2 adhesives (P<.05) in the masticatory efficacy for filters 2 and 3, and nonsignificant differences occurred for filter 1. Compared with the edentulous control group, significant differences between the use or nonuse of adhesives were found in the edentulous group for the 3 filters (P<.05). Compared with the dentate control group, significant differences were found in masticatory efficiency between the dentate control group and the other groups for all comparisons (P<.05). CONCLUSIONS: Masticatory efficacy was higher with the use of Corega denture adhesive. The masticatory efficacy was significantly higher in dentate participants compared with participants with edentulism who had complete dentures, with or without denture adhesives. A significant increase of masticatory efficacy was observed among edentulous participants with denture adhesives in relation to those not using denture adhesives. |
Cantudo-Sanagustín, E; Gutiérrez-Corrales, A; Vigo-Martínez, M; Serrera-Figallo, M -A; Torres-Lagares, D; Gutiérrez-Pérez, J -L Pathogenesis and clinicohistopathological caractheristics of melanoacanthoma: A systematic review Artículo de revista Journal of Clinical and Experimental Dentistry, 8 (3), pp. e327-e336, 2016, ISSN: 19895488. Resumen | Enlaces | BibTeX | Etiquetas: @article{Cantudo-Sanagustín2016e327, title = {Pathogenesis and clinicohistopathological caractheristics of melanoacanthoma: A systematic review}, author = {E Cantudo-Sanagustín and A Gutiérrez-Corrales and M Vigo-Martínez and M -A Serrera-Figallo and D Torres-Lagares and J -L Gutiérrez-Pérez}, url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930645/}, doi = {10.4317/jced.52860}, issn = {19895488}, year = {2016}, date = {2016-07-01}, journal = {Journal of Clinical and Experimental Dentistry}, volume = {8}, number = {3}, pages = {e327-e336}, abstract = {Introduction The melanoacanthoma is a rare benign pigmented tumor, characterized by a fast radial growth and clinical behavior similar to melanoma. Color changes in oral mucosa and dermis are consequence of increased melanocyte activity as response to an irritant factor. There is a vast phenotypic variety. It is difficult to distinguish between a benign pigmented lesion and a melanoma at its early stage. Due to its clinical relevance is crucial to diagnose possible malignancy of the lesions. Objectives The aim of this article is to conduct a systematic review of all published articles, as well as update and evaluate etiologic factors and clinicopathological features. Material and Methods We carried out a search in the Medline database (PubMed) using the key words “oral melanoacanthoma” AND “oral melanoacanthosis” AND “oral melanoepithelioma”. Inclusion criteria were all published articles since its discovery. Demographic data, histological features and immunohistochemical findings were extracted from the full articles. Results A total of 56 articles were analysed. 114 injuries drawn from these articles were studied, a total of 115 injuries with our contribution case. The 74.78% of authors claim a reactive pathogenesis. The average age of lesión appearance is 34.79 years, with an age range of 5-87 years. There is a predominance of the female sex in solitary phenotype 3: 2 and a ratio of women to men 5: 3 if it is multifocal phenotype. Bilateral phenotype is slight higher in women of 2: 1. Conclusions Histopathological analysis of the lesión is vital to diagnose malignancy. Therefore, any heterogeneous, pigmented lesion with irregular edges, raised surface, fast growth and abrupt appearance should be biopsied. More emphasis on the potential irritants should also be put to improve the quality of life of our patients and to reduce morbidity of melanoacanthoma, as well as, several similar clinical behavior disease. Key words: Melanoacanthoma, oral cáncer, diagnosis.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Introduction The melanoacanthoma is a rare benign pigmented tumor, characterized by a fast radial growth and clinical behavior similar to melanoma. Color changes in oral mucosa and dermis are consequence of increased melanocyte activity as response to an irritant factor. There is a vast phenotypic variety. It is difficult to distinguish between a benign pigmented lesion and a melanoma at its early stage. Due to its clinical relevance is crucial to diagnose possible malignancy of the lesions. Objectives The aim of this article is to conduct a systematic review of all published articles, as well as update and evaluate etiologic factors and clinicopathological features. Material and Methods We carried out a search in the Medline database (PubMed) using the key words “oral melanoacanthoma” AND “oral melanoacanthosis” AND “oral melanoepithelioma”. Inclusion criteria were all published articles since its discovery. Demographic data, histological features and immunohistochemical findings were extracted from the full articles. Results A total of 56 articles were analysed. 114 injuries drawn from these articles were studied, a total of 115 injuries with our contribution case. The 74.78% of authors claim a reactive pathogenesis. The average age of lesión appearance is 34.79 years, with an age range of 5-87 years. There is a predominance of the female sex in solitary phenotype 3: 2 and a ratio of women to men 5: 3 if it is multifocal phenotype. Bilateral phenotype is slight higher in women of 2: 1. Conclusions Histopathological analysis of the lesión is vital to diagnose malignancy. Therefore, any heterogeneous, pigmented lesion with irregular edges, raised surface, fast growth and abrupt appearance should be biopsied. More emphasis on the potential irritants should also be put to improve the quality of life of our patients and to reduce morbidity of melanoacanthoma, as well as, several similar clinical behavior disease. Key words: Melanoacanthoma, oral cáncer, diagnosis. |
a Castillo-Oyagüe, R; a Suárez-García, M -J; a Perea, C; a Río, J D; b Lynch, C D; a Gonzalo, E; c Torres-Lagares, D; a Preciado, A Validation of a new, specific, complete, and short OHRQoL scale (QoLFAST-10) for wearers of implant overdentures and fixed-detachable hybrid prostheses Artículo de revista Journal of Dentistry, 49 , pp. 22-32, 2016, (cited By 0). Resumen | Enlaces | BibTeX | Etiquetas: @article{Castillo-Oyagüe201622, title = {Validation of a new, specific, complete, and short OHRQoL scale (QoLFAST-10) for wearers of implant overdentures and fixed-detachable hybrid prostheses}, author = {R a Castillo-Oyagüe and M -J a Suárez-García and C a Perea and J D a Río and C D b Lynch and E a Gonzalo and D c Torres-Lagares and A a Preciado}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84964864272&partnerID=40&md5=ac355092f9c6fc5148c8e47daec74fd8}, doi = {10.1016/j.jdent.2016.04.011}, year = {2016}, date = {2016-01-01}, journal = {Journal of Dentistry}, volume = {49}, pages = {22-32}, abstract = {Objectives To validate a new index for assessing the whole concept of oral health-related quality of life (OHRQoL) of implant-prosthesis wearers. Methods 113 patients who were not requesting dental treatment were assigned to: Group 1 (CD; n = 38): complete denture users (control); Group 2 (IO; n = 38): implant overdenture wearers; and Group 3 (HP; n = 37): hybrid implant prosthesis users. Patients answered the newly-designed 'Quality of Life related to Function, Aesthetics, Socialization, and Thoughts about health-behavioural habits' (QoLFAST-10) and the Oral Health Impact Profile (OHIP-20sp) questionnaires. Information on global oral satisfaction, socio-demographic, clinical, and prosthetic-related data were gathered. The QoLFAST-10 was investigated for reliability and validity. The Spearman's test determined the correlations between both indices' scores. Descriptive and non-parametric probes were run to assess the influence of the study variables on the OHRQoL (α = 0.05). Results The QoLFAST-10 confirmed its psychometric capacity. HP wearers reported significantly better global and functional satisfaction than did IO wearers. The latter revealed significantly less consciousness about the importance of health-behavioural habits than did CD and HP groups. The level of education, complaints about the mouth, and the global oral satisfaction measures significantly modulated the QoLFAST-10 scores. Conclusions Implant overdentures supplied lower functional and global satisfaction than did hybrid prostheses, and represent the least predictable option concerning the maintenance of the restoration. Clinical significance The QoLFAST-10 may help in estimating the impact of implant restorations on patients' well-being. In this regard, hybrid prostheses seem to be the implant treatment of choice when compared with overdentures. © 2016 Elsevier Ltd. All rights reserved.}, note = {cited By 0}, keywords = {}, pubstate = {published}, tppubtype = {article} } Objectives To validate a new index for assessing the whole concept of oral health-related quality of life (OHRQoL) of implant-prosthesis wearers. Methods 113 patients who were not requesting dental treatment were assigned to: Group 1 (CD; n = 38): complete denture users (control); Group 2 (IO; n = 38): implant overdenture wearers; and Group 3 (HP; n = 37): hybrid implant prosthesis users. Patients answered the newly-designed 'Quality of Life related to Function, Aesthetics, Socialization, and Thoughts about health-behavioural habits' (QoLFAST-10) and the Oral Health Impact Profile (OHIP-20sp) questionnaires. Information on global oral satisfaction, socio-demographic, clinical, and prosthetic-related data were gathered. The QoLFAST-10 was investigated for reliability and validity. The Spearman's test determined the correlations between both indices' scores. Descriptive and non-parametric probes were run to assess the influence of the study variables on the OHRQoL (α = 0.05). Results The QoLFAST-10 confirmed its psychometric capacity. HP wearers reported significantly better global and functional satisfaction than did IO wearers. The latter revealed significantly less consciousness about the importance of health-behavioural habits than did CD and HP groups. The level of education, complaints about the mouth, and the global oral satisfaction measures significantly modulated the QoLFAST-10 scores. Conclusions Implant overdentures supplied lower functional and global satisfaction than did hybrid prostheses, and represent the least predictable option concerning the maintenance of the restoration. Clinical significance The QoLFAST-10 may help in estimating the impact of implant restorations on patients' well-being. In this regard, hybrid prostheses seem to be the implant treatment of choice when compared with overdentures. © 2016 Elsevier Ltd. All rights reserved. |
a Wainwright, M; b Torres-Lagares, D; b Pérez-Dorao, B; b Serrera-Figallo, M -A; b Gutierrez-Perez, J -L; c Troedhan, A; d Kurrek, A Histological and histomorphometric study using an ultrasonic crestal sinus grafting procedure. A multicenter case study Artículo de revista Medicina Oral, Patologia Oral y Cirugia Bucal, 21 (3), pp. e367-e373, 2016, (cited By 0). Resumen | Enlaces | BibTeX | Etiquetas: @article{Wainwright2016e367, title = {Histological and histomorphometric study using an ultrasonic crestal sinus grafting procedure. A multicenter case study}, author = {M a Wainwright and D b Torres-Lagares and B b Pérez-Dorao and M -A b Serrera-Figallo and J -L b Gutierrez-Perez and A c Troedhan and A d Kurrek}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84964897815&partnerID=40&md5=3ac6380017bb8c233a19ff17545a514d}, doi = {10.4317/medoral.20994}, year = {2016}, date = {2016-01-01}, journal = {Medicina Oral, Patologia Oral y Cirugia Bucal}, volume = {21}, number = {3}, pages = {e367-e373}, abstract = {Background: The aim of this study was to evaluate the efficacy of a hydrodynamic ultrasonic driven transcrestal sinus grafting procedure (Intralift ®, Acteon Company, Bordeaux, France) and the use of a bovine high temperature sintered grafting material in sinus sites with less than 5 mm remaining bone height with no additional autogenous bone in order to create a sufficient recipient site for implants. Material and Methods: 12 patients (16 sinus) in this multicenter case study were included. Using a crestal approach, bone under the sinus was prepared with ultrasonic tips until the Schneiderian membrane was reached. With a trumpet shaped instrument, the Schneiderian membrane was elevated. In the new created subantral space a high temperature sintered bovine grafting material was introduced (Bego Oss, BEGO Implant Systems GmbH & Co. KG, Bremen, Germany). After 6 months biopsies were taken with a trephine bur and histologies were generated following histomorphometric analysis. Results: The results showed new vital bone in average of 33.4% ± 17.05%, and 43.6% ± 16.70 of bone substitute material. No signs of abnormal inflammation were observed. Conclusions: This procedure (Intralift ®) allows, using a bovine material with no additional autogenous bone, new bone formation in the sinus in order to allow place implant subantraly. © Medicina Oral S. L. C.I.F.}, note = {cited By 0}, keywords = {}, pubstate = {published}, tppubtype = {article} } Background: The aim of this study was to evaluate the efficacy of a hydrodynamic ultrasonic driven transcrestal sinus grafting procedure (Intralift ®, Acteon Company, Bordeaux, France) and the use of a bovine high temperature sintered grafting material in sinus sites with less than 5 mm remaining bone height with no additional autogenous bone in order to create a sufficient recipient site for implants. Material and Methods: 12 patients (16 sinus) in this multicenter case study were included. Using a crestal approach, bone under the sinus was prepared with ultrasonic tips until the Schneiderian membrane was reached. With a trumpet shaped instrument, the Schneiderian membrane was elevated. In the new created subantral space a high temperature sintered bovine grafting material was introduced (Bego Oss, BEGO Implant Systems GmbH & Co. KG, Bremen, Germany). After 6 months biopsies were taken with a trephine bur and histologies were generated following histomorphometric analysis. Results: The results showed new vital bone in average of 33.4% ± 17.05%, and 43.6% ± 16.70 of bone substitute material. No signs of abnormal inflammation were observed. Conclusions: This procedure (Intralift ®) allows, using a bovine material with no additional autogenous bone, new bone formation in the sinus in order to allow place implant subantraly. © Medicina Oral S. L. C.I.F. |